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Table 1 Clinicopathological Characteristics of the study cohort

From: Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection

Characteristics Training cohort(n = 201) Validation cohort(n = 68) P Value
Gender    0.639
 Female 50 (24.9) 15 (22.1)  
 Male 151 (75.1) 53 (77.9)  
Age 62.7 ± 11.6 62.8 ± 11.9 0.956
KFI    0.257
  < 2 125 (62.19) 37 (54.41)  
  ≥ 2 76 (37.81) 31 (45.59)  
Smoking    0.679
 No 121 (60.2) 39 (57.35)  
 Yes 80 (39.8) 29 (42.65)  
pT    0.359
 T1 41 (20.4) 12 (17.65)  
 T2 63 (31.34) 21 (30.88)  
 T3 54 (26.87) 15 (22.06)  
 T4 43 (21.39) 20 (29.41)  
pN    0.259
 N0 31 (15.42) 9 (13.24)  
 N1 53 (26.37) 14 (20.59)  
 N2 110 (54.73) 40 (58.82)  
 N3 7 (3.48) 5 (7.35)  
AJCC Stage    0.544
 III 61 (30.3) 18 (26.5)  
 IV 140 (69.7) 50 (73.5)  
Perineural invasion    0.931
 No 120 (59.7) 41 (60.3)  
 Yes 81 (40.3) 27 (39.7)  
Tumor differentiation    0.640
 Well differentiated 87 (43.3) 25 (36.8)  
 Moderately differentiated 51 (25.4) 19 (27.9)  
 Poorly differentiated 63 (31.3) 24 (35.3)  
Depth of tumor invasion    0.268
  < 20 mm 127 (63.2) 48 (70.6)  
  ≥ 20 mm 74 (36.8) 20 (29.4)  
Number of Positive Nodes    0.648
 0 84 (41.79) 31 (45.6)  
 1–2 58 (28.86) 21 (30.9)  
 3–4 34 (16.92) 9 (13.2)  
  ≥ 5 25 (12.44) 7 (10.3)  
Lymphovascular invasion (%)    0.189
 No 41 (20.4) 9 (13.24)  
 Yes 160 (79.6) 59 (86.76)  
Primary Tumor Site    0.570
 Tongue 69 (34.33) 21 (30.88)  
 Floor of mouth 60 (29.85) 25 (36.76)  
 Other 72 (35.82) 22 (32.35)  
Extracapsular extension    0.537
 No 158 (78.61) 51 (75)  
 Yes 43 (21.39) 17 (25)  
Bone invasion    0.366
 No 119 (59.2) 36 (52.94)  
 Yes 82 (40.8) 32 (47.06)  
Safety Margins    0.408
  < 5 mm 45 (22.39) 12 (17.65)  
  ≥ 5 mm 156 (77.61) 56 (82.35)  
SII    0.580
  < 535.5 120 (59.7) 38 (55.88)  
  ≥ 535.5 81 (40.3) 30 (44.12)  
NLR    0.480
  < 2.8 125 (62.19) 39 (57.35)  
  ≥ 2.8 76 (37.81) 29 (42.65)  
PLR    0.761
  < 162.5 114 (56.72) 40 (58.82)  
  ≥ 162.5 87 (43.28) 28 (41.18)  
  1. Abbreviations: AJCC American Joint Committee on Cancer, KFI Kaplan-Feinstein index, NLR neutrophil-lymphocyte ratio, PLR platelet–lymphocyte ratio, SII systematic immune-inflammation index