Factors | Cancer specific survival | Overall survival | ||||||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||||||
HNM | P value | BM | P value | HNM | P value | BM | P value | |
Age | ||||||||
  ≤ 58 / ≤63 | Reference |  | Reference |  | Reference |  | Reference |  |
 59–78 / 64–79 | 1.398 (1.211–1.613) | < 0.001 | 1.401 (1.289–1.522) | < 0.001 | 2.570 (2.318–2.849) | < 0.001 | 2.743 (2.583–2.912) | < 0.001 |
  ≥ 79 / ≥80 | 2.218 (1.891–2.602) | < 0.001 | 2.488 (2.237–2.766) | < 0.001 | 7.667 (6.918–8.497) | < 0.001 | 8.031 (7.519–8.578) | < 0.001 |
Sex | ||||||||
 Male | Reference |  | Reference |  | Reference |  | Reference |  |
 Female | 0.790 (0.686–0.908) | 0.001 | 0.693 (0.641–0.749) | < 0.001 | 0.854 (0.784–0.930) | < 0.001 | 0.662 (0.629–0.698) | < 0.001 |
Histology | ||||||||
 NM | Reference |  | Reference |  | Reference |  | Reference |  |
 LMM | 0.538 (0.432–0.670) | < 0.001 | 0.566 (0.427–0.749) | < 0.001 | 0.795 (0.701–0.902) | < 0.001 | 0.988 (0.879–1.110) | 0.841 |
 SMM | 0.834 (0.712–0.978) | 0.025 | 0.615 (0.556–0.680) | < 0.001 | 0.851 (0.760–0.953) | 0.005 | 0.724 (0.674–0.778) | < 0.001 |
 aOther | 0.607 (0.513–0.718) | < 0.001 | 0.813 (0.732–0.903) | < 0.001 | 0.655 (0.580–0.740) | < 0.001 | 0.811 (0.749–0.878) | < 0.001 |
Thickness | ||||||||
  < 0.6 mm | Reference |  | Reference |  | Reference |  | Reference |  |
 0.6–0.79 mm | 1.564 (1.141–2.144) | 0.005 | 1.383 (1.102–1.735) | 0.005 | 1.205 (1.037–1.401) |  0.015 |  1.096 (0.987-1.217) |  0.086 |
 0.8–1.0 mm | 2.156 (1.610–2.888) | < 0.001 | 2.255 (1.851–2.746) | < 0.001 | 1.264 (1.079–1.480) | 0.005 | 1.235 (1.109–1.375) | <0.001 |
 1.01–2.0 mm | 3.292 (2.649–4.092) | < 0.001 | 3.192 (2.736–3.723) | < 0.001 | 1.558 (1.384–1.754) | < 0.001 | 1.446 (1.330–1.572) | < 0.001 |
 2.01–4.0 mm | 3.952 (3.146–4.965) | < 0.001 | 4.376 (3.724–5.142) | < 0.001 | 1.768 (1.552–2.015) | < 0.001 | 1.958 (1.785–2.147) | < 0.001 |
  > 4.0 mm | 4.417 (3.438–5.673) | < 0.001 | 5.613 (4.738–6.650) | < 0.001 | 2.080 (1.788–2.419) | < 0.001 | 2.524 (2.280–2.793) | < 0.001 |
Ulceration | ||||||||
 No | Reference |  | Reference |  | Reference |  | Reference |  |
 Yes | 1.842 (1.615–2.102) | < 0.001 | 2.225 (2.036–2.431) | < 0.001 | 1.472 (1.340–1.618) | < 0.001 | 1.775 (1.665–1.892) | < 0.001 |
Stage | ||||||||
 Localized | Reference |  | Reference |  | Reference |  | Reference |  |
 Regional | 2.547 (2.196–2.954) | < 0.001 | 3.179 (2.902–3.482) | < 0.001 | 1.677 (1.502–1.874) | < 0.001 | 2.044 (1.909–2.190) | < 0.001 |
 Distant | 3.683 (2.013–6.737) | < 0.001 | 5.245 (4.064–6.768) | < 0.001 | 2.434 (1.523–3.891) | < 0.001 | 3.667 (2.932–4.587) | < 0.001 |
Metastases | ||||||||
 No | Reference |  | Reference |  | Reference |  | Reference |  |
 Yes | 2.323 (1.237–4.364) | 0.009 | 2.545 (1.939–3.342) | < 0.001 | 2.061 (1.244–3.413) | 0.005 | 2.276 (1.779–2.912) | < 0.001 |
Surgery | ||||||||
 No | Reference |  | Reference |  | Reference |  | Reference |  |
 Yes | 0.369 (0.262–0.519) | < 0.001 | 0.536 (0.410–0.701) | < 0.001 | 0.568 (0.457–0.708) | < 0.001 | 0.510 (0.432–0.603) | < 0.001 |