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Table 1 Patient characteristics

From: Combining tissue and circulating tumor DNA increases the detection rate of a CTNNB1 mutation in hepatocellular carcinoma

 

Plasma

Tumor tissue

CTNNB1 mutation positive

CTNNB1 mutation negative

P value

CTNNB1 mutation positive

CTNNB1 mutation negative

P value

All

(n = 9)

(n = 86)

 

(n = 3)

(n = 34)

 

 Age

68 (64–82)

72 (66–78)

0.992

65 (55–86)

75 (67–81)

0.559

 Sex

  Women

5 (55.6%)

19 (22.1%)

0.028

2 (66.7%)

6 (17.6%)

0.112

  Men

4 (44.4%)

67 (77.9%)

 

1 (33.3%)

28 (82.4%)

 

 Cirrosis

  Yes

6 (66.7%)

54 (62.8%)

0.918

2 (66.7%)

12 (35.3%)

0.538

  No

3 (33.3%)

25 (29.1%)

 

1 (33.3%)

19 (55.9%)

 

  Unknown

7 (8.1%)

 

3 (8.8%)

 

 Child Pugh stage

  Noncirrhosis

3 (33.3%)

32 (37.2%)

 

1 (33.3%)

22 (64.7%)

 

  A

1 (11.1%)

26 (30.2%)

0.160

1 (33.3%)

7 (20.6%)

0.825

  B

5 (55.6%)

23 (26.7%)

 

1 (33.3%)

5 (14.7%)

 

  C

5 (5.8%)

 

 

 Cirrhosis etiology

  Alcohol

2 (22.2%)

29 (33.7%)

0.802

1 (33.3%)

9 (26.5%)

0.469

  Hepatitis C

3 (33.3%)

10 (11.6%)

0.071

1 (33.3%)

3 (8.8%)

0.469

  Non alcoholic steatohepatitis

4 (4.7%)

0.509

1 (2.9%)

0.672

  Other (AIH/haemochromatosis)

7 (8.1%)

0.374

1 (2.9%)

0.672

  Unknown/no cirrhosis

4 (44.4%)

36 (41.9%)

0.881

1 (33.3%)

20 (58.8%)

0.393

 Barcelona Clinic Liver Cancer stage

  0

2 (22.2%)

9 (10.5%)

0.857

2 (5.9%)

0.872

  A

1 (11.1%)

13 (15.1%)

 

1 (33.3%)

9 (26.5%)

 

  B

1 (11.1%)

9 (10.5%)

 

7 (20.6%)

 

  C

5 (55.6%)

50 (58.1%)

 

2 (66.7%)

15 (44.1%)

 

  D

5 (5.8%)

 

1 (2.9%)

 

 TNM stage

  I

2 (22.2%)

29 (33.7%)

0.914

2 (66.7%)

12 (35.3%)

0.478

  II

2 (22.2%)

18 (20.9%)

 

1 (33.3%)

6 (17.6%)

 

  III

2 (22.2%)

16 (18.6%)

 

6 (17.6%)

 

  IV

3 (33.3%)

23 (26.7%)

 

10 (29.4%)

 

 Vascular invasion

0 (0.0%)

19 (22.1%)

0.115

0 (0.0%)

4 (11.8%)

0.529

 Alpha-fetoprotein

  < 20 ng/mL

5 (55.6%)

36 (41.9%)

0.642

2 (66.7%)

16 (63.1%)

0.658

  ≥ 20 ng/mL

4 (44.4%)

40 (46.5%)

 

1 (33.3%)

14 (41.2%)

 

  Not available

10 (11.6%)

  

4 (11.8%)