Plasma | Tumor tissue | |||||
---|---|---|---|---|---|---|
CTNNB1 mutation positive | CTNNB1 mutation negative | P value | CTNNB1 mutation positive | CTNNB1 mutation negative | P value | |
All | (n = 9) | (n = 86) | (n = 3) | (n = 34) | ||
Age | 68 (64–82) | 72 (66–78) | 0.992 | 65 (55–86) | 75 (67–81) | 0.559 |
Sex | ||||||
Women | 5 (55.6%) | 19 (22.1%) | 0.028 | 2 (66.7%) | 6 (17.6%) | 0.112 |
Men | 4 (44.4%) | 67 (77.9%) | 1 (33.3%) | 28 (82.4%) | ||
Cirrosis | ||||||
Yes | 6 (66.7%) | 54 (62.8%) | 0.918 | 2 (66.7%) | 12 (35.3%) | 0.538 |
No | 3 (33.3%) | 25 (29.1%) | 1 (33.3%) | 19 (55.9%) | ||
Unknown | – | 7 (8.1%) | – | 3 (8.8%) | ||
Child Pugh stage | ||||||
Noncirrhosis | 3 (33.3%) | 32 (37.2%) | 1 (33.3%) | 22 (64.7%) | ||
A | 1 (11.1%) | 26 (30.2%) | 0.160 | 1 (33.3%) | 7 (20.6%) | 0.825 |
B | 5 (55.6%) | 23 (26.7%) | 1 (33.3%) | 5 (14.7%) | ||
C | – | 5 (5.8%) | – | – | ||
Cirrhosis etiology | ||||||
Alcohol | 2 (22.2%) | 29 (33.7%) | 0.802 | 1 (33.3%) | 9 (26.5%) | 0.469 |
Hepatitis C | 3 (33.3%) | 10 (11.6%) | 0.071 | 1 (33.3%) | 3 (8.8%) | 0.469 |
Non alcoholic steatohepatitis | – | 4 (4.7%) | 0.509 | – | 1 (2.9%) | 0.672 |
Other (AIH/haemochromatosis) | – | 7 (8.1%) | 0.374 | – | 1 (2.9%) | 0.672 |
Unknown/no cirrhosis | 4 (44.4%) | 36 (41.9%) | 0.881 | 1 (33.3%) | 20 (58.8%) | 0.393 |
Barcelona Clinic Liver Cancer stage | ||||||
0 | 2 (22.2%) | 9 (10.5%) | 0.857 | – | 2 (5.9%) | 0.872 |
A | 1 (11.1%) | 13 (15.1%) | 1 (33.3%) | 9 (26.5%) | ||
B | 1 (11.1%) | 9 (10.5%) | – | 7 (20.6%) | ||
C | 5 (55.6%) | 50 (58.1%) | 2 (66.7%) | 15 (44.1%) | ||
D | – | 5 (5.8%) | – | 1 (2.9%) | ||
TNM stage | ||||||
I | 2 (22.2%) | 29 (33.7%) | 0.914 | 2 (66.7%) | 12 (35.3%) | 0.478 |
II | 2 (22.2%) | 18 (20.9%) | 1 (33.3%) | 6 (17.6%) | ||
III | 2 (22.2%) | 16 (18.6%) | – | 6 (17.6%) | ||
IV | 3 (33.3%) | 23 (26.7%) | – | 10 (29.4%) | ||
Vascular invasion | 0 (0.0%) | 19 (22.1%) | 0.115 | 0 (0.0%) | 4 (11.8%) | 0.529 |
Alpha-fetoprotein | ||||||
< 20 ng/mL | 5 (55.6%) | 36 (41.9%) | 0.642 | 2 (66.7%) | 16 (63.1%) | 0.658 |
≥ 20 ng/mL | 4 (44.4%) | 40 (46.5%) | 1 (33.3%) | 14 (41.2%) | ||
Not available | – | 10 (11.6%) | 4 (11.8%) |