TY - JOUR AU - Mahmood, Reem D. AU - Shaw, Danielle AU - Descamps, Tine AU - Zhou, Cong AU - Morgan, Robert D. AU - Mullamitha, Saifee AU - Saunders, Mark AU - Mescallado, Nerissa AU - Backen, Alison AU - Morris, Karen AU - Little, Ross A. AU - Cheung, Susan AU - Watson, Yvonne AU - O’Connor, James P. B. AU - Jackson, Alan AU - Parker, Geoff J. M. AU - Dive, Caroline AU - Jayson, Gordon C. PY - 2021 DA - 2021/04/01 TI - Effect of oxaliplatin plus 5-fluorouracil or capecitabine on circulating and imaging biomarkers in patients with metastatic colorectal cancer: a prospective biomarker study JO - BMC Cancer SP - 354 VL - 21 IS - 1 AB - Patients with metastatic colorectal cancer are treated with cytotoxic chemotherapy supplemented by molecularly targeted therapies. There is a critical need to define biomarkers that can optimise the use of these therapies to maximise efficacy and avoid unnecessary toxicity. However, it is important to first define the changes in potential biomarkers following cytotoxic chemotherapy alone. This study reports the impact of standard cytotoxic chemotherapy across a range of circulating and imaging biomarkers. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-021-08097-9 DO - 10.1186/s12885-021-08097-9 ID - Mahmood2021 ER -