A new risk-stratification system for hepatoblastoma in children under six years old and the significance for prognosis evaluation—a 14-year retrospective study from a single center

Table 3 The clinical characteristics and univariate analysis of 382 HB children^a

Group		n	Percent(%)	χ²	P value
Sex	Male	231	60.5	2.766	0.633
Sex	Female	151	39.5	2.766	0.633
Age (years)	<1	128	33.5	9.053	0.021
	1–3	184	48.2
	> 3 and < 6 y	70	18.3
AFP at first visit (ng/ml)	<100	25	6.5	12.697	<0.001
	100–1000	120	31.4
	>1000	237	62.1
Platelet count at first visit (×10⁹/L)	≤400	167	43.7	11.367	0.001
Platelet count at first visit (×10⁹/L)	>400	215	56.3	11.367	0.001
Pathological classification	Epithelial type	213	55.8	8.535	0.013
Pathological classification	Mixed	169	44.2	8.535	0.013
PRETEXT staging	I period	9	2.4	19.233	<0.001
	II period	97	25.4
	III period	224	58.6
	IV period	52	13.6
Portal venous involvement (P) and/or hepatic venous/IVC^b involvement (V)	Yes	86	22.5	14.643	<0.001
	No	296	77.5	14.643	<0.001
Extrahepatic tumor extension (E)	Yes	73	19.1	4.872	0.459
Extrahepatic tumor extension (E)	No	309	80.9	4.872	0.459
Tumor rupture (R)	Yes	24	6.3	2.176	0.251
Tumor rupture (R)	No	358	93.7	2.176	0.251
Metastasis (M)	Yes	171	44.8	9.766	0.001
Metastasis (M)	No	211	55.2	9.766	0.001
Multifocality (F)	Yes	96	25.1	9.041	0.002
Multifocality (F)	No	286	74.9	9.041	0.002
Complete resection of primary tumor	Yes	283	74.1	1.690	0.345
Complete resection of primary tumor	No	99	25.9	1.690	0.345

^aIt was a univariate Cox regression of five-year OS separately on each of the clinical characteristic
^bIVC inferior vena cava

ISSN: 1471-2407