The prognostic significance of combined geriatric nutritional risk index and psoas muscle volume in older patients with pancreatic cancer

Table 2 Potential prognostic factors for overall survival in patients aged ≥65 years with pancreatic cancer

	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P	HR	95% CI	P
Sex (male vs. female)	1.771	1.043–3.006	0.034	1.463	0.814–2.629	0.204
Age (≥ 75 years vs. < 75 years)	1.111	0.675–1.830	0.678
Body mass index (< 20.5 mm vs. ≥ 20.5 mm)	2.946	1.781–4.873	< 0.001	2.048	1.105–3.796	0.023
Tumor size (≥ 20.0 mm vs. < 20.0 mm)	2.383	1.170–4.855	0.017	2.829	1.297–6.174	0.009
Tumor location (head vs. body and tail)	1.135	0.688–1.874	0.620
Histological grading for primary tumor (G1 vs. other)	0.667	0.372–1.194	0.173
Lymph node metastasis (present vs. absent)	2.736	1.604–4.666	< 0.001	2.552	1.466–4.443	0.001
ASA-PS (3 vs. 1 or 2)	1.500	0.837–2.687	0.173
Preoperative CA19–9 (≥ 152.8 U/mL vs. < 152.8 U/mL)	1.987	1.185–3.330	0.009	1.272	0.749–2.161	0.373
Combination of the GNRI and PMV (Group C vs. Group A and Group B	3.852	2.321–6.393	< 0.001	2.866	1.490–5.513	0.002

Abbreviations: HR Hazard ratio; CI Confidence interval; G1 Well-differentiated; ASA-PS American Society of Anesthesiologists physical status; CA19–9 Carbohydrate antigen 19–9; GNRI Geriatric nutritional risk index; PMV Total psoas muscle volume; Group A, both high GNRI and high PMV; Group B, high GNRI or high PMV (but not both); Group C, both low GNRI and low PMV

ISSN: 1471-2407