Polymorphism | Comparison | Subgroup | N | PH | PZ | PAdjust | OR & 95%CI (Random) | OR & 95%CI (Fixed) |
---|---|---|---|---|---|---|---|---|
rs11079571 | B vs. A | Overall | 3 | < 0.001 | 0.005 | 0.025* | 0.459(0.266–0.794) | 0.539(0.478–0.609) |
rs11079571 | BB vs. AA | Overall | 3 | 0.001 | < 0.001 | < 0.001* | 0.2(0.085–0.469) | 0.22(0.164–0.295) |
rs11079571 | BA vs. AA | Overall | 3 | 0.081 | < 0.001 | < 0.001* | 0.322(0.192–0.54) | 0.292(0.216–0.394) |
rs11079571 | BB + BA vs. AA | Overall | 3 | 0.08 | < 0.001 | < 0.001* | 0.265(0.162–0.433) | 0.249(0.189–0.33) |
rs11079571 | BB vs. BA+ AA | Overall | 3 | < 0.001 | 0.022 | 0.11 | 0.436(0.215–0.887) | 0.619(0.531–0.723) |
rs11079571 | B vs. A | Asian | 2 | 0.002 | 0.001 | 0.005* | 0.351(0.191–0.646) | 0.407(0.345–0.479) |
rs11079571 | BB vs. AA | Asian | 2 | 0.007 | < 0.001 | < 0.001* | 0.135(0.045–0.407) | 0.178(0.127–0.251) |
rs11079571 | BA vs. AA | Asian | 2 | 0.416 | < 0.001 | < 0.001* | 0.246(0.174–0.346) | 0.247(0.175–0.348) |
rs11079571 | BB + BA vs. AA | Asian | 2 | 0.575 | < 0.001 | < 0.001* | 0.216(0.157–0.297) | 0.215(0.156–0.295) |
rs11079571 | BB vs. BA+ AA | Asian | 2 | < 0.001 | 0.083 | 0.415 | 0.311(0.083–1.166) | 0.463(0.368–0.582) |
rs11079571 | B vs. A | Breast Cancer | 2 | < 0.001 | 0.148 | 0.74 | 0.446 (0.150–1.332) | 0.594(0.507–0.697) |
rs11079571 | BB vs. AA | Breast Cancer | 2 | < 0.001 | 0.056 | 0.28 | 0.182(0.032–1.047) | 0.209(0.133–0.329) |
rs11079571 | BA vs. AA | Breast Cancer | 2 | 0.289 | < 0.001 | < 0.001* | 0.419(0.255–0.689) | 0.416(0.261–0.662) |
rs11079571 | BB + BA vs. AA | Breast Cancer | 2 | 0.041 | 0.009 | 0.045* | 0.294(0.118–0.734) | 0.285(0.184–0.441) |
rs11079571 | BB vs. BA+ AA | Breast Cancer | 2 | < 0.001 | 0.202 | 1 | 0.356(0.073–1.74) | 0.63(0.52–0.764) |
rs1133683 | B vs. A | Overall | 6 | < 0.001 | 0.664 | 1.000 | 1.076(0.773–1.498) | 1.14(1.021–1.273) |
rs1133683 | BB vs. AA | Overall | 6 | < 0.001 | 0.005 | 0.025* | 0.258(0.101–0.657) | 0.391(0.284–0.539) |
rs1133683 | BA vs. AA | Overall | 6 | < 0.001 | 0.036 | 0.18 | 2.079(1.048–4.126) | 2.298(1.948–2.71) |
rs1133683 | BB + BA vs. AA | Overall | 6 | < 0.001 | 0.1 | 0.5 | 1.78(0.895–3.538) | 1.962(1.673–2.301) |
rs1133683 | BB vs. BA+ AA | Overall | 6 | < 0.001 | < 0.001 | < 0.001* | 0.162(0.08–0.328) | 0.206(0.152–0.278) |
rs1133683 | B vs. A | Asian | 5 | < 0.001 | 0.2 | 1.000 | 1.212(0.904–1.625) | 1.25(1.11–1.408) |
rs1133683 | BB vs. AA | Asian | 5 | < 0.001 | 0.026 | 0.13 | 0.283(0.093–0.858) | 0.469(0.329–0.67) |
rs1133683 | BA vs. AA | Asian | 5 | < 0.001 | 0.01 | 0.05 | 2.51(1.247–5.052) | 2.627(2.203–3.132) |
rs1133683 | BB + BA vs. AA | Asian | 5 | < 0.001 | 0.025 | 0.125 | 2.186(1.105–4.322) | 2.283(1.926–2.707) |
rs1133683 | BB vs. BA+ AA | Asian | 5 | < 0.001 | < 0.001 | < 0.001* | 0.154(0.062–0.383) | 0.21(0.15–0.295) |
rs1133683 | B vs. A | PB | 4 | < 0.001 | 0.828 | 1.000 | 1.051(0.67–1.651) | 1.146(1.01–1.302) |
rs1133683 | BB vs. AA | PB | 4 | 0.006 | 0.001 | 0.005* | 0.256(0.113–0.584) | 0.349(0.241–0.504) |
rs1133683 | BA vs. AA | PB | 4 | < 0.001 | 0.118 | 0.59 | 2.112(0.827–5.395) | 2.541(2.093–3.084) |
rs1133683 | BB + BA vs. AA | PB | 4 | < 0.001 | 0.23 | 1.000 | 1.773(0.696–4.515) | 2.142(1.777–2.582) |
rs1133683 | BB vs. BA+ AA | PB | 4 | 0.045 | < 0.001 | < 0.001* | 0.16(0.086–0.297) | 0.184(0.13–0.259) |
rs1133683 | B vs. A | HB | 2 | 0.004 | 0.72 | 1.000 | 1.127(0.587–2.163) | 1.12(0.895–1.401) |
rs1133683 | BB vs. AA | HB | 2 | < 0.001 | 0.46 | 1.000 | 0.265(0.008–8.979) | 0.556(0.291–1.062) |
rs1133683 | BA vs. AA | HB | 2 | < 0.001 | 0.249 | 1.000 | 2.001(0.615–6.508) | 1.788(1.305–2.45) |
rs1133683 | BB + BA vs. AA | HB | 2 | < 0.001 | 0.361 | 1.000 | 1.782(0.515–6.161) | 1.572(1.159–2.132) |
rs1133683 | BB vs. BA+ AA | HB | 2 | < 0.001 | 0.186 | 0.93 | 0.166(0.012–2.381) | 0.297(0.158–0.559) |
rs1133683 | B vs. A | Lung Cancer | 2 | 0.016 | 0.767 | 1.000 | 1.071(0.68–1.687) | 1.196(1.023–1.399) |
rs1133683 | BB vs. AA | Lung Cancer | 2 | 0.228 | 0.008 | 0.04* | 0.491(0.263–0.918) | 0.53(0.333–0.845) |
rs1133683 | BA vs. AA | Lung Cancer | 2 | < 0.001 | 0.317 | 1.000 | 2.143(0.482–9.522) | 2.695(2.109–3.442) |
rs1133683 | BB + BA vs. AA | Lung Cancer | 2 | < 0.001 | 0.387 | 1.000 | 1.888(0.448–7.959) | 2.36(1.86–2.995) |
rs1133683 | BB vs. BA+ AA | Lung Cancer | 2 | 0.39 | < 0.001 | < 0.001* | 0.21(0.136–0.325) | 0.212(0.138–0.328) |
rs1133683 | B vs. A | Y | 5 | < 0.001 | 0.898 | 1.000 | 1.028(0.673–1.571) | 1.036(0.899–1.193) |
rs1133683 | BB vs. AA | Y | 5 | < 0.001 | 0.008 | 0.04* | 0.211(0.067–0.666) | 0.293(0.195–0.44) |
rs1133683 | BA vs. AA | Y | 5 | < 0.001 | 0.14 | 0.7 | 1.767(0.83–3.762) | 1.753(1.434–2.142) |
rs1133683 | BB + BA vs. AA | Y | 5 | < 0.001 | 0.287 | 1.000 | 1.512(0.706–3.241) | 1.499(1.236–1.818) |
rs1133683 | BB vs. BA+ AA | Y | 5 | < 0.001 | < 0.001 | < 0.001* | 0.152(0.057–0.405) | 0.215(0.146–0.315) |
rs2240308 | B vs. A | Overall | 20 | < 0.001 | 0.402 | 1.000 | 0.949(0.841–1.072) | 0.962(0.906–1.02) |
rs2240308 | BB vs. AA | Overall | 19 | < 0.001 | 0.722 | 1.000 | 0.952(0.726–1.248) | 0.966(0.849–1.1) |
rs2240308 | BA vs. AA | Overall | 19 | 0.016 | 0.089 | 0.445 | 0.887(0.773–1.018) | 0.915(0.834–1.004) |
rs2240308 | BB + BA vs. AA | Overall | 19 | < 0.001 | 0.176 | 0.88 | 0.895(0.763–1.051) | 0.923(0.846–1.007) |
rs2240308 | BB vs. BA+ AA | Overall | 19 | < 0.001 | 0.963 | 1.000 | 1.005(0.811–1.246) | 1.006(0.895–1.13) |
rs2240308 | B vs. A | Asian | 15 | 0.01 | 0.017 | 0.085 | 0.867(0.772–0.974) | 0.879(0.815–0.947) |
rs2240308 | BB vs. AA | Asian | 15 | 0.019 | 0.072 | 0.36 | 0.799(0.626–1.021) | 0.806(0.686–0.946) |
rs2240308 | BA vs. AA | Asian | 15 | 0.268 | 0.002 | 0.01* | 0.828(0.731–0.939) | 0.84(0.753–0.937) |
rs2240308 | BB + BA vs. AA | Asian | 15 | 0.066 | 0.004 | 0.02* | 0.811(0.704–0.934) | 0.835(0.754–0.926) |
rs2240308 | BB vs. BA+ AA | Asian | 15 | 0.053 | 0.273 | 1.000 | 0.889(0.721–1.097) | 0.874(0.754–1.013) |
rs2240308 | B vs. A | Caucasian | 5 | < 0.001 | 0.138 | 0.69 | 1.228(0.936–1.61) | 1.119(1.016–1.233) |
rs2240308 | BB vs. AA | Caucasian | 4 | < 0.001 | 0.082 | 0.41 | 2.069(0.912–4.692) | 1.375(1.101–1.716) |
rs2240308 | BA vs. AA | Caucasian | 4 | 0.044 | 0.224 | 1.000 | 1.253(0.871–1.801) | 1.141(0.957–1.36) |
rs2240308 | BB + BA vs. AA | Caucasian | 4 | 0.002 | 0.143 | 0.715 | 1.421(0.888–2.274) | 1.198(1.014–1.414) |
rs2240308 | BB vs. BA+ AA | Caucasian | 4 | 0.001 | 0.112 | 0.56 | 1.6(0.896–2.858) | 1.277(1.053–1.548) |
rs2240308 | B vs. A | PB | 12 | < 0.001 | 0.894 | 1.000 | 0.987(0.815–1.195) | 0.944(0.871–1.022) |
rs2240308 | BB vs. AA | PB | 12 | < 0.001 | 0.955 | 1.000 | 1.012(0.67–1.529) | 0.919(0.777–1.087) |
rs2240308 | BA vs. AA | PB | 12 | 0.064 | 0.364 | 1.000 | 0.924(0.78–1.096) | 0.913(0.81–1.028) |
rs2240308 | BB + BA vs. AA | PB | 12 | < 0.001 | 0.644 | 1.000 | 0.949(0.762–1.183) | 0.911(0.814–1.019) |
rs2240308 | BB vs. BA+ AA | PB | 12 | < 0.001 | 0.893 | 1.000 | 1.023(0.734–1.425) | 0.96(0.823–1.119) |
rs2240308 | B vs. A | HB | 8 | 0.114 | 0.719 | 1.000 | 0.935(0.822–1.064) | 0.984(0.901–1.075) |
rs2240308 | BB vs. AA | HB | 7 | 0.376 | 0.705 | 1.000 | 1.015(0.812–1.27) | 1.04(0.849–1.273) |
rs2240308 | BA vs. AA | HB | 7 | 0.047 | 0.1 | 0.5 | 0.839(0.681–1.034) | 0.919(0.808–1.045) |
rs2240308 | BB + BA vs. AA | HB | 7 | 0.043 | 0.128 | 0.64 | 0.855(0.699–1.046) | 0.937(0.828–1.06) |
rs2240308 | BB vs. BA+ AA | HB | 7 | 0.684 | 0.444 | 1.000 | 1.075(0.897–1.287) | 1.073(0.896–1.284) |
rs2240308 | B vs. A | Colorectal Cancer | 4 | 0.15 | 0.056 | 0.28 | 1.108(0.918–1.336) | 1.116(0.997–1.249) |
rs2240308 | BB vs. AA | Colorectal Cancer | 4 | 0.192 | 0.031 | 0.155 | 1.314(0.903–1.911) | 1.295(1.024–1.637) |
rs2240308 | BA vs. AA | Colorectal Cancer | 4 | 0.2 | 0.548 | 1.000 | 1.031(0.779–1.363) | 1.057(0.882–1.266) |
rs2240308 | BB + BA vs. AA | Colorectal Cancer | 4 | 0.113 | 0.252 | 1.000 | 1.083(0.794–1.478) | 1.105(0.931–1.312) |
rs2240308 | BB vs. BA+ AA | Colorectal Cancer | 4 | 0.563 | 0.036 | 0.18 | 1.241(1.011–1.524) | 1.245(1.015–1.527) |
rs2240308 | B vs. A | Prostate Cancer | 2 | 0.099 | 0.452 | 1.000 | 0.828(0.507–1.353) | 0.832(0.619–1.119) |
rs2240308 | BB vs. AA | Prostate Cancer | 2 | 0.509 | 0.987 | 1.000 | 1.004(0.539–1.869) | 1.005(0.54–1.871) |
rs2240308 | BA vs. AA | Prostate Cancer | 2 | 0.088 | 0.127 | 0.635 | 0.555(0.26–1.183) | 0.542(0.35–0.84) |
rs2240308 | BB + BA vs. AA | Prostate Cancer | 2 | 0.078 | 0.219 | 1.000 | 0.633(0.305–1.313) | 0.62(0.412–0.934) |
rs2240308 | BB vs. BA+ AA | Prostate Cancer | 2 | 0.872 | 0.39 | 1.000 | 1.284(0.726–2.27) | 1.284(0.726–2.27) |
rs2240308 | B vs. A | Lung Cancer | 6 | < 0.001 | 0.176 | 0.88 | 0.854(0.678–1.074) | 0.875(0.791–0.967) |
rs2240308 | BB vs. AA | Lung Cancer | 6 | < 0.001 | 0.199 | 0.995 | 0.714(0.427–1.194) | 0.776(0.626–0.962) |
rs2240308 | BA vs. AA | Lung Cancer | 6 | 0.317 | 0.069 | 0.345 | 0.868(0.736–1.023) | 0.873(0.755–1.01) |
rs2240308 | BB + BA vs. AA | Lung Cancer | 6 | 0.022 | 0.218 | 1.000 | 0.827(0.648–1.056) | 0.857(0.747–0.983) |
rs2240308 | BB vs. BA+ AA | Lung Cancer | 6 | 0.002 | 0.272 | 1.000 | 0.784(0.508–1.211) | 0.817(0.669–0.998) |
rs2240308 | B vs. A | Y | 16 | < 0.001 | 0.099 | 0.495 | 0.899(0.792–1.02) | 0.928(0.866–0.994) |
rs2240308 | BB vs. AA | Y | 16 | 0.001 | 0.281 | 1.000 | 0.862(0.659–1.129) | 0.904(0.78–1.048) |
rs2240308 | BA vs. AA | Y | 16 | 0.097 | 0.018 | 0.09 | 0.843(0.732–0.972) | 0.874(0.786–0.971) |
rs2240308 | BB + BA vs. AA | Y | 16 | 0.008 | 0.03 | 0.15 | 0.838(0.714–0.983) | 0.875(0.792–0.967) |
rs2240308 | BB vs. BA+ AA | Y | 16 | 0.011 | 0.604 | 1.000 | 0.945(0.761–1.172) | 0.962(0.843–1.099) |
rs2240308 | B vs. A | N | 4 | < 0.001 | 0.347 | 1.000 | 1.174(0.84–1.64) | 1.056(0.944–1.182) |
rs2240308 | BB vs. AA | N | 3 | < 0.001 | 0.21 | 1.000 | 1.961(0.684–5.618) | 1.199(0.922–1.561) |
rs2240308 | BA vs. AA | N | 3 | 0.022 | 0.468 | 1.000 | 1.171(0.765–1.793) | 1.066(0.88–1.292) |
rs2240308 | BB + BA vs. AA | N | 3 | 0.001 | 0.347 | 1.000 | 1.304(0.75–2.265) | 1.095(0.915–1.31) |
rs2240308 | BB vs. BA+ AA | N | 3 | < 0.001 | 0.243 | 1.000 | 1.648(0.713–3.81) | 1.176(0.919–1.504) |
rs35285779 | B vs. A | Overall | 4 | 0.068 | 0.011 | 0.055 | 0.603(0.409–0.889) | 0.632(0.496–0.806) |
rs35285779 | BB vs. AA | Overall | 4 | 0.378 | 0.038 | 0.19 | 0.43(0.194–0.955) | 0.368(0.176–0.77) |
rs35285779 | BA vs. AA | Overall | 4 | 0.384 | 0.009 | 0.045* | 0.685(0.513–0.915) | 0.684(0.514–0.909) |
rs35285779 | BB + BA vs. AA | Overall | 4 | 0.155 | 0.001 | 0.005* | 0.613(0.421–0.893) | 0.639(0.486–0.839) |
rs35285779 | BB vs. BA+ AA | Overall | 4 | 0.448 | 0.017 | 0.085 | 0.473(0.219–1.025) | 0.408(0.195–0.853) |
rs35285779 | B vs. A | PB | 2 | 0.172 | 0.034 | 0.17 | 0.691(0.442–1.08) | 0.711(0.519–0.975) |
rs35285779 | BB vs. AA | PB | 2 | 0.352 | 0.145 | 0.725 | 0.452(0.147–1.388) | 0.443(0.148–1.323) |
rs35285779 | BA vs. AA | PB | 2 | 0.434 | 0.102 | 0.51 | 0.741(0.517–1.062) | 0.741(0.517–1.062) |
rs35285779 | BB + BA vs. AA | PB | 2 | 0.257 | 0.057 | 0.285 | 0.702(0.467–1.054) | 0.713(0.504–1.01) |
rs35285779 | BB vs. BA+ AA | PB | 2 | 0.393 | 0.197 | 0.985 | 0.498(0.163–1.52) | 0.488(0.164–1.452) |
rs35285779 | B vs. A | HB | 2 | 0.041 | 0.103 | 0.515 | 0.508(0.226–1.145) | 0.535(0.365–0.783) |
rs35285779 | BB vs. AA | HB | 2 | 0.131 | 0.025 | 0.125 | 0.262(0.028–2.443) | 0.317(0.116–0.868) |
rs35285779 | BA vs. AA | HB | 2 | 0.161 | 0.031 | 0.155 | 0.592(0.305–1.149) | 0.598(0.375–0.954) |
rs35285779 | BB + BA vs. AA | HB | 2 | 0.081 | 0.104 | 0.52 | 0.519(0.236–1.144) | 0.535(0.344–0.833) |
rs35285779 | BB vs. BA+ AA | HB | 2 | 0.16 | 0.043 | 0.215 | 0.311(0.041–2.355) | 0.354(0.13–0.967) |
rs35285779 | B vs. A | Lung Cancer | 2 | 0.172 | 0.034 | 0.17 | 0.691(0.442–1.08) | 0.711(0.519–0.975) |
rs35285779 | BB vs. AA | Lung Cancer | 2 | 0.352 | 0.145 | 0.725 | 0.452(0.147–1.388) | 0.443(0.148–1.323) |
rs35285779 | BA vs. AA | Lung Cancer | 2 | 0.434 | 0.102 | 0.51 | 0.741(0.517–1.062) | 0.741(0.517–1.062) |
rs35285779 | BB + BA vs. AA | Lung Cancer | 2 | 0.257 | 0.057 | 0.285 | 0.702(0.467–1.054) | 0.713(0.504–1.01) |
rs35285779 | BB vs. BA+ AA | Lung Cancer | 2 | 0.393 | 0.197 | 0.985 | 0.498(0.163–1.52) | 0.488(0.164–1.452) |
rs7219582 | B vs. A | Overall | 4 | 0.386 | 0.077 | 0.385 | 0.822(0.645–1.048) | 0.82(0.659–1.021) |
rs7219582 | BA vs. AA | Overall | 4 | 0.035 | 0.538 | 1.000 | 0.75(0.3–1.873) | 0.491(0.344–0.7) |
rs7219582 | BB + BA vs. AA | Overall | 4 | 0.045 | 0.538 | 1.000 | 0.758(0.313–1.833) | 0.51(0.358–0.727) |
rs7219582 | B vs. A | Lung Cancer | 2 | 0.941 | 0.041 | 0.205 | 0.789(0.629–0.99) | 0.789(0.629–0.99) |
rs7219582 | BA vs. AA | Lung Cancer | 2 | 0.399 | < 0.001 | < 0.001* | 0.394(0.265–0.586) | 0.394(0.265–0.585) |
rs7219582 | BB + BA vs. AA | Lung Cancer | 2 | 0.436 | < 0.001 | < 0.001* | 0.414(0.278–0.614) | 0.413(0.278–0.614) |
rs9915936 | B vs. A | Overall | 4 | 0.873 | 0.038 | 0.19 | 0.708(0.51–0.981) | 0.707(0.51–0.981) |
rs9915936 | BA vs. AA | Overall | 4 | 0.668 | 0.014 | 0.07 | 0.634(0.44–0.914) | 0.633(0.44–0.91) |
rs9915936 | BB + BA vs. AA | Overall | 4 | 0.775 | 0.021 | 0.105 | 0.662(0.466–0.94) | 0.661(0.466–0.939) |
rs9915936 | B vs. A | PB | 2 | 0.806 | 0.034 | 0.17 | 0.667(0.459–0.971) | 0.667(0.459–0.97) |
rs9915936 | BA vs. AA | PB | 2 | 0.548 | 0.009 | 0.045* | 0.567(0.369–0.871) | 0.566(0.369–0.87) |
rs9915936 | BB + BA vs. AA | PB | 2 | 0.669 | 0.016 | 0.08 | 0.607(0.404–0.913) | 0.607(0.404–0.912) |
rs9915936 | B vs. A | HB | 2 | 0.619 | 0.646 | 1.000 | 0.855(0.436–1.677) | 0.854(0.436–1.674) |
rs9915936 | BA vs. AA | HB | 2 | 0.608 | 0.637 | 1.000 | 0.848(0.425–1.692) | 0.847(0.425–1.689) |
rs9915936 | BB + BA vs. AA | HB | 2 | 0.608 | 0.637 | 1.000 | 0.848(0.425–1.692) | 0.847(0.425–1.689) |
rs9915936 | B vs. A | Lung Cancer | 2 | 0.806 | 0.034 | 0.17 | 0.667(0.459–0.971) | 0.667(0.459–0.97) |
rs9915936 | BA vs. AA | Lung Cancer | 2 | 0.548 | 0.009 | 0.045* | 0.567(0.369–0.871) | 0.566(0.369–0.87) |
rs9915936 | BB + BA vs. AA | Lung Cancer | 2 | 0.669 | 0.016 | 0.08 | 0.607(0.404–0.913) | 0.607(0.404–0.912) |