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Table 2 Results of pooled analysis for AXIN2 Polymorphism and cancer susceptibility

From: New insights of the correlation between AXIN2 polymorphism and cancer risk and susceptibility: evidence from 72 studies

Polymorphism

Comparison

Subgroup

N

PH

PZ

PAdjust

OR & 95%CI (Random)

OR & 95%CI (Fixed)

rs11079571

B vs. A

Overall

3

< 0.001

0.005

0.025*

0.459(0.266–0.794)

0.539(0.478–0.609)

rs11079571

BB vs. AA

Overall

3

0.001

< 0.001

< 0.001*

0.2(0.085–0.469)

0.22(0.164–0.295)

rs11079571

BA vs. AA

Overall

3

0.081

< 0.001

< 0.001*

0.322(0.192–0.54)

0.292(0.216–0.394)

rs11079571

BB + BA vs. AA

Overall

3

0.08

< 0.001

< 0.001*

0.265(0.162–0.433)

0.249(0.189–0.33)

rs11079571

BB vs. BA+ AA

Overall

3

< 0.001

0.022

0.11

0.436(0.215–0.887)

0.619(0.531–0.723)

rs11079571

B vs. A

Asian

2

0.002

0.001

0.005*

0.351(0.191–0.646)

0.407(0.345–0.479)

rs11079571

BB vs. AA

Asian

2

0.007

< 0.001

< 0.001*

0.135(0.045–0.407)

0.178(0.127–0.251)

rs11079571

BA vs. AA

Asian

2

0.416

< 0.001

< 0.001*

0.246(0.174–0.346)

0.247(0.175–0.348)

rs11079571

BB + BA vs. AA

Asian

2

0.575

< 0.001

< 0.001*

0.216(0.157–0.297)

0.215(0.156–0.295)

rs11079571

BB vs. BA+ AA

Asian

2

< 0.001

0.083

0.415

0.311(0.083–1.166)

0.463(0.368–0.582)

rs11079571

B vs. A

Breast Cancer

2

< 0.001

0.148

0.74

0.446 (0.150–1.332)

0.594(0.507–0.697)

rs11079571

BB vs. AA

Breast Cancer

2

< 0.001

0.056

0.28

0.182(0.032–1.047)

0.209(0.133–0.329)

rs11079571

BA vs. AA

Breast Cancer

2

0.289

< 0.001

< 0.001*

0.419(0.255–0.689)

0.416(0.261–0.662)

rs11079571

BB + BA vs. AA

Breast Cancer

2

0.041

0.009

0.045*

0.294(0.118–0.734)

0.285(0.184–0.441)

rs11079571

BB vs. BA+ AA

Breast Cancer

2

< 0.001

0.202

1

0.356(0.073–1.74)

0.63(0.52–0.764)

rs1133683

B vs. A

Overall

6

< 0.001

0.664

1.000

1.076(0.773–1.498)

1.14(1.021–1.273)

rs1133683

BB vs. AA

Overall

6

< 0.001

0.005

0.025*

0.258(0.101–0.657)

0.391(0.284–0.539)

rs1133683

BA vs. AA

Overall

6

< 0.001

0.036

0.18

2.079(1.048–4.126)

2.298(1.948–2.71)

rs1133683

BB + BA vs. AA

Overall

6

< 0.001

0.1

0.5

1.78(0.895–3.538)

1.962(1.673–2.301)

rs1133683

BB vs. BA+ AA

Overall

6

< 0.001

< 0.001

< 0.001*

0.162(0.08–0.328)

0.206(0.152–0.278)

rs1133683

B vs. A

Asian

5

< 0.001

0.2

1.000

1.212(0.904–1.625)

1.25(1.11–1.408)

rs1133683

BB vs. AA

Asian

5

< 0.001

0.026

0.13

0.283(0.093–0.858)

0.469(0.329–0.67)

rs1133683

BA vs. AA

Asian

5

< 0.001

0.01

0.05

2.51(1.247–5.052)

2.627(2.203–3.132)

rs1133683

BB + BA vs. AA

Asian

5

< 0.001

0.025

0.125

2.186(1.105–4.322)

2.283(1.926–2.707)

rs1133683

BB vs. BA+ AA

Asian

5

< 0.001

< 0.001

< 0.001*

0.154(0.062–0.383)

0.21(0.15–0.295)

rs1133683

B vs. A

PB

4

< 0.001

0.828

1.000

1.051(0.67–1.651)

1.146(1.01–1.302)

rs1133683

BB vs. AA

PB

4

0.006

0.001

0.005*

0.256(0.113–0.584)

0.349(0.241–0.504)

rs1133683

BA vs. AA

PB

4

< 0.001

0.118

0.59

2.112(0.827–5.395)

2.541(2.093–3.084)

rs1133683

BB + BA vs. AA

PB

4

< 0.001

0.23

1.000

1.773(0.696–4.515)

2.142(1.777–2.582)

rs1133683

BB vs. BA+ AA

PB

4

0.045

< 0.001

< 0.001*

0.16(0.086–0.297)

0.184(0.13–0.259)

rs1133683

B vs. A

HB

2

0.004

0.72

1.000

1.127(0.587–2.163)

1.12(0.895–1.401)

rs1133683

BB vs. AA

HB

2

< 0.001

0.46

1.000

0.265(0.008–8.979)

0.556(0.291–1.062)

rs1133683

BA vs. AA

HB

2

< 0.001

0.249

1.000

2.001(0.615–6.508)

1.788(1.305–2.45)

rs1133683

BB + BA vs. AA

HB

2

< 0.001

0.361

1.000

1.782(0.515–6.161)

1.572(1.159–2.132)

rs1133683

BB vs. BA+ AA

HB

2

< 0.001

0.186

0.93

0.166(0.012–2.381)

0.297(0.158–0.559)

rs1133683

B vs. A

Lung Cancer

2

0.016

0.767

1.000

1.071(0.68–1.687)

1.196(1.023–1.399)

rs1133683

BB vs. AA

Lung Cancer

2

0.228

0.008

0.04*

0.491(0.263–0.918)

0.53(0.333–0.845)

rs1133683

BA vs. AA

Lung Cancer

2

< 0.001

0.317

1.000

2.143(0.482–9.522)

2.695(2.109–3.442)

rs1133683

BB + BA vs. AA

Lung Cancer

2

< 0.001

0.387

1.000

1.888(0.448–7.959)

2.36(1.86–2.995)

rs1133683

BB vs. BA+ AA

Lung Cancer

2

0.39

< 0.001

< 0.001*

0.21(0.136–0.325)

0.212(0.138–0.328)

rs1133683

B vs. A

Y

5

< 0.001

0.898

1.000

1.028(0.673–1.571)

1.036(0.899–1.193)

rs1133683

BB vs. AA

Y

5

< 0.001

0.008

0.04*

0.211(0.067–0.666)

0.293(0.195–0.44)

rs1133683

BA vs. AA

Y

5

< 0.001

0.14

0.7

1.767(0.83–3.762)

1.753(1.434–2.142)

rs1133683

BB + BA vs. AA

Y

5

< 0.001

0.287

1.000

1.512(0.706–3.241)

1.499(1.236–1.818)

rs1133683

BB vs. BA+ AA

Y

5

< 0.001

< 0.001

< 0.001*

0.152(0.057–0.405)

0.215(0.146–0.315)

rs2240308

B vs. A

Overall

20

< 0.001

0.402

1.000

0.949(0.841–1.072)

0.962(0.906–1.02)

rs2240308

BB vs. AA

Overall

19

< 0.001

0.722

1.000

0.952(0.726–1.248)

0.966(0.849–1.1)

rs2240308

BA vs. AA

Overall

19

0.016

0.089

0.445

0.887(0.773–1.018)

0.915(0.834–1.004)

rs2240308

BB + BA vs. AA

Overall

19

< 0.001

0.176

0.88

0.895(0.763–1.051)

0.923(0.846–1.007)

rs2240308

BB vs. BA+ AA

Overall

19

< 0.001

0.963

1.000

1.005(0.811–1.246)

1.006(0.895–1.13)

rs2240308

B vs. A

Asian

15

0.01

0.017

0.085

0.867(0.772–0.974)

0.879(0.815–0.947)

rs2240308

BB vs. AA

Asian

15

0.019

0.072

0.36

0.799(0.626–1.021)

0.806(0.686–0.946)

rs2240308

BA vs. AA

Asian

15

0.268

0.002

0.01*

0.828(0.731–0.939)

0.84(0.753–0.937)

rs2240308

BB + BA vs. AA

Asian

15

0.066

0.004

0.02*

0.811(0.704–0.934)

0.835(0.754–0.926)

rs2240308

BB vs. BA+ AA

Asian

15

0.053

0.273

1.000

0.889(0.721–1.097)

0.874(0.754–1.013)

rs2240308

B vs. A

Caucasian

5

< 0.001

0.138

0.69

1.228(0.936–1.61)

1.119(1.016–1.233)

rs2240308

BB vs. AA

Caucasian

4

< 0.001

0.082

0.41

2.069(0.912–4.692)

1.375(1.101–1.716)

rs2240308

BA vs. AA

Caucasian

4

0.044

0.224

1.000

1.253(0.871–1.801)

1.141(0.957–1.36)

rs2240308

BB + BA vs. AA

Caucasian

4

0.002

0.143

0.715

1.421(0.888–2.274)

1.198(1.014–1.414)

rs2240308

BB vs. BA+ AA

Caucasian

4

0.001

0.112

0.56

1.6(0.896–2.858)

1.277(1.053–1.548)

rs2240308

B vs. A

PB

12

< 0.001

0.894

1.000

0.987(0.815–1.195)

0.944(0.871–1.022)

rs2240308

BB vs. AA

PB

12

< 0.001

0.955

1.000

1.012(0.67–1.529)

0.919(0.777–1.087)

rs2240308

BA vs. AA

PB

12

0.064

0.364

1.000

0.924(0.78–1.096)

0.913(0.81–1.028)

rs2240308

BB + BA vs. AA

PB

12

< 0.001

0.644

1.000

0.949(0.762–1.183)

0.911(0.814–1.019)

rs2240308

BB vs. BA+ AA

PB

12

< 0.001

0.893

1.000

1.023(0.734–1.425)

0.96(0.823–1.119)

rs2240308

B vs. A

HB

8

0.114

0.719

1.000

0.935(0.822–1.064)

0.984(0.901–1.075)

rs2240308

BB vs. AA

HB

7

0.376

0.705

1.000

1.015(0.812–1.27)

1.04(0.849–1.273)

rs2240308

BA vs. AA

HB

7

0.047

0.1

0.5

0.839(0.681–1.034)

0.919(0.808–1.045)

rs2240308

BB + BA vs. AA

HB

7

0.043

0.128

0.64

0.855(0.699–1.046)

0.937(0.828–1.06)

rs2240308

BB vs. BA+ AA

HB

7

0.684

0.444

1.000

1.075(0.897–1.287)

1.073(0.896–1.284)

rs2240308

B vs. A

Colorectal Cancer

4

0.15

0.056

0.28

1.108(0.918–1.336)

1.116(0.997–1.249)

rs2240308

BB vs. AA

Colorectal Cancer

4

0.192

0.031

0.155

1.314(0.903–1.911)

1.295(1.024–1.637)

rs2240308

BA vs. AA

Colorectal Cancer

4

0.2

0.548

1.000

1.031(0.779–1.363)

1.057(0.882–1.266)

rs2240308

BB + BA vs. AA

Colorectal Cancer

4

0.113

0.252

1.000

1.083(0.794–1.478)

1.105(0.931–1.312)

rs2240308

BB vs. BA+ AA

Colorectal Cancer

4

0.563

0.036

0.18

1.241(1.011–1.524)

1.245(1.015–1.527)

rs2240308

B vs. A

Prostate Cancer

2

0.099

0.452

1.000

0.828(0.507–1.353)

0.832(0.619–1.119)

rs2240308

BB vs. AA

Prostate Cancer

2

0.509

0.987

1.000

1.004(0.539–1.869)

1.005(0.54–1.871)

rs2240308

BA vs. AA

Prostate Cancer

2

0.088

0.127

0.635

0.555(0.26–1.183)

0.542(0.35–0.84)

rs2240308

BB + BA vs. AA

Prostate Cancer

2

0.078

0.219

1.000

0.633(0.305–1.313)

0.62(0.412–0.934)

rs2240308

BB vs. BA+ AA

Prostate Cancer

2

0.872

0.39

1.000

1.284(0.726–2.27)

1.284(0.726–2.27)

rs2240308

B vs. A

Lung Cancer

6

< 0.001

0.176

0.88

0.854(0.678–1.074)

0.875(0.791–0.967)

rs2240308

BB vs. AA

Lung Cancer

6

< 0.001

0.199

0.995

0.714(0.427–1.194)

0.776(0.626–0.962)

rs2240308

BA vs. AA

Lung Cancer

6

0.317

0.069

0.345

0.868(0.736–1.023)

0.873(0.755–1.01)

rs2240308

BB + BA vs. AA

Lung Cancer

6

0.022

0.218

1.000

0.827(0.648–1.056)

0.857(0.747–0.983)

rs2240308

BB vs. BA+ AA

Lung Cancer

6

0.002

0.272

1.000

0.784(0.508–1.211)

0.817(0.669–0.998)

rs2240308

B vs. A

Y

16

< 0.001

0.099

0.495

0.899(0.792–1.02)

0.928(0.866–0.994)

rs2240308

BB vs. AA

Y

16

0.001

0.281

1.000

0.862(0.659–1.129)

0.904(0.78–1.048)

rs2240308

BA vs. AA

Y

16

0.097

0.018

0.09

0.843(0.732–0.972)

0.874(0.786–0.971)

rs2240308

BB + BA vs. AA

Y

16

0.008

0.03

0.15

0.838(0.714–0.983)

0.875(0.792–0.967)

rs2240308

BB vs. BA+ AA

Y

16

0.011

0.604

1.000

0.945(0.761–1.172)

0.962(0.843–1.099)

rs2240308

B vs. A

N

4

< 0.001

0.347

1.000

1.174(0.84–1.64)

1.056(0.944–1.182)

rs2240308

BB vs. AA

N

3

< 0.001

0.21

1.000

1.961(0.684–5.618)

1.199(0.922–1.561)

rs2240308

BA vs. AA

N

3

0.022

0.468

1.000

1.171(0.765–1.793)

1.066(0.88–1.292)

rs2240308

BB + BA vs. AA

N

3

0.001

0.347

1.000

1.304(0.75–2.265)

1.095(0.915–1.31)

rs2240308

BB vs. BA+ AA

N

3

< 0.001

0.243

1.000

1.648(0.713–3.81)

1.176(0.919–1.504)

rs35285779

B vs. A

Overall

4

0.068

0.011

0.055

0.603(0.409–0.889)

0.632(0.496–0.806)

rs35285779

BB vs. AA

Overall

4

0.378

0.038

0.19

0.43(0.194–0.955)

0.368(0.176–0.77)

rs35285779

BA vs. AA

Overall

4

0.384

0.009

0.045*

0.685(0.513–0.915)

0.684(0.514–0.909)

rs35285779

BB + BA vs. AA

Overall

4

0.155

0.001

0.005*

0.613(0.421–0.893)

0.639(0.486–0.839)

rs35285779

BB vs. BA+ AA

Overall

4

0.448

0.017

0.085

0.473(0.219–1.025)

0.408(0.195–0.853)

rs35285779

B vs. A

PB

2

0.172

0.034

0.17

0.691(0.442–1.08)

0.711(0.519–0.975)

rs35285779

BB vs. AA

PB

2

0.352

0.145

0.725

0.452(0.147–1.388)

0.443(0.148–1.323)

rs35285779

BA vs. AA

PB

2

0.434

0.102

0.51

0.741(0.517–1.062)

0.741(0.517–1.062)

rs35285779

BB + BA vs. AA

PB

2

0.257

0.057

0.285

0.702(0.467–1.054)

0.713(0.504–1.01)

rs35285779

BB vs. BA+ AA

PB

2

0.393

0.197

0.985

0.498(0.163–1.52)

0.488(0.164–1.452)

rs35285779

B vs. A

HB

2

0.041

0.103

0.515

0.508(0.226–1.145)

0.535(0.365–0.783)

rs35285779

BB vs. AA

HB

2

0.131

0.025

0.125

0.262(0.028–2.443)

0.317(0.116–0.868)

rs35285779

BA vs. AA

HB

2

0.161

0.031

0.155

0.592(0.305–1.149)

0.598(0.375–0.954)

rs35285779

BB + BA vs. AA

HB

2

0.081

0.104

0.52

0.519(0.236–1.144)

0.535(0.344–0.833)

rs35285779

BB vs. BA+ AA

HB

2

0.16

0.043

0.215

0.311(0.041–2.355)

0.354(0.13–0.967)

rs35285779

B vs. A

Lung Cancer

2

0.172

0.034

0.17

0.691(0.442–1.08)

0.711(0.519–0.975)

rs35285779

BB vs. AA

Lung Cancer

2

0.352

0.145

0.725

0.452(0.147–1.388)

0.443(0.148–1.323)

rs35285779

BA vs. AA

Lung Cancer

2

0.434

0.102

0.51

0.741(0.517–1.062)

0.741(0.517–1.062)

rs35285779

BB + BA vs. AA

Lung Cancer

2

0.257

0.057

0.285

0.702(0.467–1.054)

0.713(0.504–1.01)

rs35285779

BB vs. BA+ AA

Lung Cancer

2

0.393

0.197

0.985

0.498(0.163–1.52)

0.488(0.164–1.452)

rs7219582

B vs. A

Overall

4

0.386

0.077

0.385

0.822(0.645–1.048)

0.82(0.659–1.021)

rs7219582

BA vs. AA

Overall

4

0.035

0.538

1.000

0.75(0.3–1.873)

0.491(0.344–0.7)

rs7219582

BB + BA vs. AA

Overall

4

0.045

0.538

1.000

0.758(0.313–1.833)

0.51(0.358–0.727)

rs7219582

B vs. A

Lung Cancer

2

0.941

0.041

0.205

0.789(0.629–0.99)

0.789(0.629–0.99)

rs7219582

BA vs. AA

Lung Cancer

2

0.399

< 0.001

< 0.001*

0.394(0.265–0.586)

0.394(0.265–0.585)

rs7219582

BB + BA vs. AA

Lung Cancer

2

0.436

< 0.001

< 0.001*

0.414(0.278–0.614)

0.413(0.278–0.614)

rs9915936

B vs. A

Overall

4

0.873

0.038

0.19

0.708(0.51–0.981)

0.707(0.51–0.981)

rs9915936

BA vs. AA

Overall

4

0.668

0.014

0.07

0.634(0.44–0.914)

0.633(0.44–0.91)

rs9915936

BB + BA vs. AA

Overall

4

0.775

0.021

0.105

0.662(0.466–0.94)

0.661(0.466–0.939)

rs9915936

B vs. A

PB

2

0.806

0.034

0.17

0.667(0.459–0.971)

0.667(0.459–0.97)

rs9915936

BA vs. AA

PB

2

0.548

0.009

0.045*

0.567(0.369–0.871)

0.566(0.369–0.87)

rs9915936

BB + BA vs. AA

PB

2

0.669

0.016

0.08

0.607(0.404–0.913)

0.607(0.404–0.912)

rs9915936

B vs. A

HB

2

0.619

0.646

1.000

0.855(0.436–1.677)

0.854(0.436–1.674)

rs9915936

BA vs. AA

HB

2

0.608

0.637

1.000

0.848(0.425–1.692)

0.847(0.425–1.689)

rs9915936

BB + BA vs. AA

HB

2

0.608

0.637

1.000

0.848(0.425–1.692)

0.847(0.425–1.689)

rs9915936

B vs. A

Lung Cancer

2

0.806

0.034

0.17

0.667(0.459–0.971)

0.667(0.459–0.97)

rs9915936

BA vs. AA

Lung Cancer

2

0.548

0.009

0.045*

0.567(0.369–0.871)

0.566(0.369–0.87)

rs9915936

BB + BA vs. AA

Lung Cancer

2

0.669

0.016

0.08

0.607(0.404–0.913)

0.607(0.404–0.912)

  1. PH P value of Q test for heterogeneity test, PZ P value of meta-analysis, PAdjust Adjust PZ value by Bonferroni corrections, PAdjust = PZ * 5, P-B Population based, HWE Hardy Weinberg Equilibrium, Y polymorphisms conformed to HWE in the control group, N polymorphisms didn’t conform to HWE in the control group
  2. * P value less than 0.05 was considered as statistically significant