Fig. 5From: Mesenchymal stem cells accelerated growth and metastasis of neuroblastoma and preferentially homed towards both primary and metastatic loci in orthotopic neuroblastoma modelRecruitment of hMSCs by metastatic loci could not be completely inhibited by CXCR4 specific antagonist AMD3100. We traced the hMSCs trafficking in vivo by detecting the fluorescence signal of CM-DiI pre-labeled hMSCs in freshly harvested livers and lungs in Day 56 after orthotopic tumor engraftment. Fluorescence image quantified data was analyzed by un-paired one-tailed t-test. 10μg/ml AMD3100 pre-treatment could not significantly inhibit the recruitment of hMSCs towards the liver with metastatic disease (P = 0.4465, n = 3, representative results of 2 mice shown) (a), but could significantly block the recruitment towards the lung invaded with tumor cells, *indicates P = 0.04548 < 0.05 (n = 3, representative results of 2 mice shown) (b). The statistical analysis and data graphs were conducted by GraphPad Prism 5Back to article page