| |
Intervention Group
|
Usual Care
| |
|---|
|
Biomarker
|
Week 1
|
Week 12
|
Change
|
Week 12
|
Change
|
Difference of change
|
P- value
|
|---|
|
Insulin (uIU/mL; SDb)
|
16.81 (2.53)
|
21.89 (7.50)
|
5.08 (7.29)
|
25.12 (7.31)
|
8.32 (7.01)
|
−3.24 (10.11)
|
0.752
|
|
Leptin (ng/mL)
|
21.84 (5.63)
|
22.18 (5.08)
|
0.34 (3.28)
|
18.53 (5.84)
|
− 3.31 (3.50)
|
3.65 (4.55)
|
0.430
|
|
C-Reactive Protein (CRP; ng/mL)
|
4344.41 (459.07)
|
2963.07 (650.29)
|
− 1381.34 (682.02)
|
4205.55 (717.93)
|
−138.87 (665.26)
|
− 1242.47 (918.90)
|
0.188
|
|
Soluble PD-1 (pg/mL)
|
90.51 (19.86)
|
243.27 (36.44)
|
152.76 (45.51)
|
23.48 (38.69)
|
−67.03 (41.49)
|
219.79 (54.47)
|
< 0.001
|
|
Soluble PD-L1 (pg/mL)
|
9.76 (0.34)
|
10.98 (8.14)
|
1.22 (8.18)
|
22.06 (7.64)
|
12.30 (7.64)
|
−11.08 (11.17)
|
0.331
|
- a Only n = 10 patients provided baseline and follow-up samples; 6 in the intervention group and 4 in usual care
- b SD = Standard Deviation
