Table 6 Test of Biomarker Change Using a Linear Mixed Modela
Intervention Group | Usual Care | ||||||
|---|---|---|---|---|---|---|---|
Biomarker | Week 1 | Week 12 | Change | Week 12 | Change | Difference of change | P- value |
Insulin (uIU/mL; SDb) | 16.81 (2.53) | 21.89 (7.50) | 5.08 (7.29) | 25.12 (7.31) | 8.32 (7.01) | −3.24 (10.11) | 0.752 |
Leptin (ng/mL) | 21.84 (5.63) | 22.18 (5.08) | 0.34 (3.28) | 18.53 (5.84) | − 3.31 (3.50) | 3.65 (4.55) | 0.430 |
C-Reactive Protein (CRP; ng/mL) | 4344.41 (459.07) | 2963.07 (650.29) | − 1381.34 (682.02) | 4205.55 (717.93) | −138.87 (665.26) | − 1242.47 (918.90) | 0.188 |
Soluble PD-1 (pg/mL) | 90.51 (19.86) | 243.27 (36.44) | 152.76 (45.51) | 23.48 (38.69) | −67.03 (41.49) | 219.79 (54.47) | < 0.001 |
Soluble PD-L1 (pg/mL) | 9.76 (0.34) | 10.98 (8.14) | 1.22 (8.18) | 22.06 (7.64) | 12.30 (7.64) | −11.08 (11.17) | 0.331 |