Table 4 Overall Patient-Reported Outcomes by Study Group (Mixed Effects Model)
Score Type | Score at Week 1 | Intervention Group | Usual Care | Difference of score change | P-value | ||
|---|---|---|---|---|---|---|---|
Score at Week 12 | Score Change | Score at Week 12 | Score Change | ||||
European Organisation for the Research and Treatment of Cancer (EORTC) Core Quality of life Questionnaire | |||||||
Overall and Functioning Domains | |||||||
QLQ summary score | 85.08 (2.16) | 87.36 (2.64) | 2.28 (2.18) | 86.05 (2.79) | 0.97 (2.22) | 1.31 (3.02) | 0.668 |
Global health status (SE) | 73.32 (3.67) | 76.48 (4.35) | 3.16 (4.11) | 68.69 (4.77) | −4.63 (4.20) | 7.79 (5.51) | 0.166 |
Physical functioning | 84.02 (2.79) | 88.13 (3.10) | 4.11 (2.50) | 88.76 (3.31) | 4.74 (2.54) | −0.64 (3.41) | 0.853 |
Role functioning | 85.51 (3.84) | 93.60 (5.27) | 8.09 (5.33) | 76.55 (5.76) | −8.95 (5.45) | 17.04 (7.16) | 0.022 |
Emotional functioning | 85.11 (2.74) | 87.79 (3.07) | 2.68 (2.89) | 88.22 (3.38) | 3.11 (2.95) | −0.43 (3.83) | 0.911 |
Cognitive functioning | 90.93 (2.74) | 91.35 (3.02) | 0.41 (2.26) | 93.40 (3.22) | 2.47 (2.31) | −2.05 (3.13) | 0.515 |
Social functioning | 83.91 (3.41) | 79.69 (5.51) | −4.22 (5.38) | 88.31 (5.90) | 4.40 (5.50) | −8.62 (7.45) | 0.254 |
Symptom Domains | |||||||
Fatigue | 22.46 (3.51) | 18.04 (5.54) | −4.43 (4.85) | 23.21 (5.79) | 0.75 (4.97) | −5.18 (6.88) | 0.456 |
Nausea and vomiting | 6.32 (2.19) | 3.88 (4.15) | −2.44 (4.18) | 12.53 (4.42) | 6.21 (4.28) | −8.65 (5.80) | 0.144 |
Pain | 12.21 (4.06) | 13.88 (4.79) | 1.67 (4.77) | 13.47 (5.29) | 1.26 (4.87) | 0.41 (6.28) | 0.948 |
Dyspnea | 23.31 (4.06) | 17.12 (5.15) | −6.19 (4.88) | 30.43 (5.60) | 7.12 (4.99) | −13.31 (6.62) | 0.051 |
Insomnia | 19.64 (4.40) | 20.22 (6.47) | 0.58 (6.37) | 16.15 (6.99) | −3.49 (6.52) | 4.07 (8.71) | 0.643 |
Appetite loss | 12.24 (3.92) | 8.08 (5.89) | −4.16 (6.60) | 17.19 (6.49) | 4.95 (6.73) | −9.11 (8.50) | 0.290 |
Constipation | 14.84 (4.83) | 13.63 (5.17) | −1.21 (4.02) | 3.64 (5.57) | −11.19 (4.11) | 9.99 (5.49) | 0.077 |
Diarrhoea | 8.89 (3.64) | 9.03 (3.77) | 0.14 (3.32) | 3.76 (4.15) | −5.13 (3.39) | 5.27 (4.38) | 0.237 |
Financial Difficulties | 15.08 (4.76) | 21.64 (6.72) | 6.56 (4.54) | 20.49 (6.76) | 5.41 (4.65) | 1.15 (6.49) | 0.861 |
MMRC Dyspnea Scale | 1.03 (0.17) | 0.99 (0.19) | −0.04 (0.15) | 0.96 (0.20) | −0.07 (0.15) | 0.03 (0.20) | 0.889 |
PHQ-9 Total Score (omits Q10) | 3.55 (0.62) | 2.72 (0.70) | −0.83 (0.65) | 3.86 (0.78) | 0.31 (0.68) | −1.14 (0.88) | 0.203 |