Fig. 4
From: Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells
Proteins found to be affected upon siRNA-mediated knock-down of LRP/LR using SWATH-MS based proteomics in late (DLD-1) stage colorectal cancer cells. Only proteins with p-values < 0.05 were considered significant. Red dots indicated proteins that were significantly up-regulated, while blue dots show proteins that were significantly down-regulated. (a) esiRNA-RLUC-transfected vs Human-RPSA siRNA- samples. It was found that there was a large, significant effect on the proteome of Human-RPSA siRNA transfected samples when they were compared to esiRNA-RLUC negative control samples. (b) Heat-map illustrating up- and down-regulated proteins upon siRNA-mediated knock-down of LRP/LR. Proteins which were up-regulated upon transfection with Human-RPSA siRNA are shown in red, while down-regulated proteins are indicated in green