Fig. 3
From: Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells
Relative mRNA expression levels of specific proteins in late (DLD-1) colorectal cancer cells. (a) Transfection with Human-RPSA siRNA showed that relative p53 mRNA expression levels increased by 1.7-fold, (b) Bax increased by 4-fold and (d) CREB increased by 4-fold when compared with non-transfected cells. (c) Upon transfection with Human-RPSA, relative Bcl-2 mRNA expression levels decreased by 0.4-fold in comparison to non-transfected cells. esiRNA-RLUC served as the negative control for each experiment. All data represent three biological replicates with two technical repeats with newly transfected samples each time. *p < 0.05, **p < 0.01, ***p < 0.001, significant: A One-way ANOVA and a Bonferroni corrected post-hoc t-test was performed