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Table 7 Cox regression model testing the tumor microenvironment metascore as a continuous variable in the IMvigor 210 study

From: RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer

  Hazard Ratio 95% CI P-value
ECOG (0 vs 1 or 2) 2.42 1.73–3.38 < 0.001 ***
TMB 0.96 0.94–0.98 < 0.001 ***
IC PD-L1    0.522
IC0 vs IC1 1.04 0.72–1.51 0.843
IC0 vs IC2+ 0.84 0.55–1.28 0.416
Metascore 4.11 1.97–8.59 < 0.001 ***
  1. *** Statistically significant at p-value < 0.001