RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer

Table 4 Spearman bivariate correlation coefficients of DDR gene mutations, DDR deep deletions, predicted SNV neoantigens, Non-silent muts/Mb (TMB) and TILs fraction

	No. DDR mutations	No. DDR Deep deletions	Predicted SNV neoantigens	TMB	TILs fraction
No. DDR mutations	1.00	0.09	0.77**	0.80**	0.26**
No. DDR Deep deletions	0.09	1.00	0.17**	0.19**	−0.04
Predicted SNV neoantigens	0.77**	0.17**	1.00	0.95**	0.26**
TMB	0.80**	0.19**	0.95**	1.00	0.29**
TILs fraction	0.26**	−0.04	0.26**	0.29**	1.00

ISSN: 1471-2407