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Table 3 Mean number of deleteriously mutated and deleted DDR genes (± sd) in MIBC patients with RB1 and TP53 alterations

From: RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer

  No. Mutated DDR genes (a) No. Deleted DDR genes (b)
DWT 2.2 ± 3.2 1.0 ± 2.0
RB1 only 3.2 ± 4.0 3.0 ± 3.7
TP53 only 3.2 ± 2.6 1.2 ± 2.3
RB1 & TP53 3.7 ± 2.8 2.2 ± 3.3
Kruskal-Wallis (p value) a < 0.001 b < 0.001
RB1 WT 2.6 ± 3.0 1.1 ± 2.1
RB1 MUT 3.2 ± 2.8 1.9 ± 3.2
RB1 HD 4.1 ± 3.7 3.4 ± 3.6
Kruskal-Wallis (p value) a 0.003 b < 0.001
TP53 WT 2.4 ± 3.3 1.3 ± 2.4
TP53 TRUNCATED 3.8 ± 2.6 1.4 ± 2.8
TP53 MISSENSE 3.3 ± 2.7 1.5 ± 2.4
Kruskal-Wallis (p value) a < 0.001 b 0.47