Table 3 Mean number of deleteriously mutated and deleted DDR genes (± sd) in MIBC patients with RB1 and TP53 alterations

DWT

2.2 ± 3.2

1.0 ± 2.0

RB1 only

3.2 ± 4.0

3.0 ± 3.7

TP53 only

3.2 ± 2.6

1.2 ± 2.3

RB1 & TP53

3.7 ± 2.8

2.2 ± 3.3

Kruskal-Wallis (p value)

a < 0.001

b < 0.001

RB1 WT

2.6 ± 3.0

1.1 ± 2.1

RB1 MUT

3.2 ± 2.8

1.9 ± 3.2

RB1 HD

4.1 ± 3.7

3.4 ± 3.6

Kruskal-Wallis (p value)

a 0.003

b < 0.001

TP53 WT

2.4 ± 3.3

1.3 ± 2.4

TP53 TRUNCATED

3.8 ± 2.6

1.4 ± 2.8

TP53 MISSENSE

3.3 ± 2.7

1.5 ± 2.4

Kruskal-Wallis (p value)

a < 0.001

b 0.47