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Table 3 Univariate and multivariate analysis of various prognostic factors

From: Nodular lymphocyte-predominant Hodgkin lymphoma characteristics, management of primary and relapsed/refractory disease and outcome analysis: the first comprehensive report from the Middle East

Kaplan Meier 5 years EFS and OS
Univariate Analysis
Covariates / different groups Stage I-II
EFS
Stage III-IV
EFS
Stage III-IV
OS
  % p-value % p-value % p-value
Female 71.4 0.57 21.4 0.82 91 0.74
Male 72.2   40   87  
Age < 21 69.2 0.56 48.4 0.151 95.5 0.71
Age > 21 75.1   26   81.6  
Age < 30 69 0.55 45.8 0.29 97 0.093
Age > 30 79.3   18.6   71  
Performance status 0–1 71.7 * 33.7 0.54 87 0.48
Performance status > 2 100   0   75  
B symptoms - No 71.6 * 34.4 0.98 88.4 0.86
B symptoms - Yes 100   57.1   87.5  
Hemoglobin > 10.5 77.7 0.9 50.5 0.011 86.8 0.13
Hemoglobin < 10.5 85.7   16.7   67  
Albumin > 4 80.2 0.047 53.8 0.005 92 0.061
Albumin < 4 60   20   70  
LDH not elevated 82.7 0.007 67.3 0.012 100 0.025
LDH elevated 61   19   75  
Bulky disease No 73 0.59 35.5 0.26 89.2 0.72
Bulky disease Yes 85.7   31.8   81  
Spleen involvement - No 72.2 * 38.6 0.058 89.2 0.8
Spleen involvement - Yes 100   27.1   84.4  
Extranodal involvement - No 72.4 0.72 34.7 0.34 87 0.51
Extranodal involvement - Yes 66.7   32.8   87.5  
Bone marrow positive 34.2 0.35 86.4 0.46
Bone marrow negative    0   100  
GHSG - Early favorable 79    
GHSG - Early Unfavorable 60.2 0.04     
Radiation given 79.2 0.03 50 0.27 75 0.91
Radiation not given 63.8   35   86  
Multivariate Analysis
  HR** 95% CI** HR 95% CI (range) HR 95% CI (range)
GHSG Early favorable 1   -***
GHSG Early unfavorable 3.84 1.44 -10.25     
Hemoglobin > 10.5 1  
Hemoglobin < 10.5    4.862 1.5-15.76   
Albumin > 4 1  
Albumin < 4    4.359 1.492-12.74   
  1. *All the cases censored; no statistics performed (in stage I-II, performance status > 2 in only 1 patient, B symptoms - Yes in 3 patients, spleen involvement in only 1 patient.). **Hazard ratio (HR), confidence interval, Lower - Upper limits (CI), other abbreviation as per Table 1. ***no factor showed significance on multivariate analysis
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