First cycle | Reduction after cycle 2, n (%) | |||||
G-CSF type | N | No | Yes | |||
Overall | 234 | 198 (84.6) | 36 (15.4) | |||
No G-CSF administration | 60 | 52 (86.7) | 8 (13.3) | |||
Daily G-CSF | 122 | 104 (85.2) | 18 (14.8) | |||
Pegfilgrastim | 52 | 42 (80.8) | 10 (19.2) | |||
Multivariate analysis a: Dose reduction Objective variable (0: no reduction, 1: dose reduction) | Parameter estimate | Standard error | Odds ratio | p value | ||
OR | 95% CI | |||||
FN onset in cycle 1 (absent, present) | 1.7488 | 0.4672 | 5.748 | 2.301, 14.359 | 0.0002 | |
Sex (male, female) | 0.9693 | 0.4122 | 2.636 | 1.175, 5.914 | 0.0187 | |
Delay after cycle 2, n (%) | ||||||
No | Yes | |||||
Overall | 234 | 137 (58.5) | 97 (41.5) | |||
No G-CSF administration | 60 | 36 (60.0) | 24 (40.0) | |||
Daily G-CSF | 122 | 68 (55.7) | 54 (44.3) | |||
Pegfilgrastim | 52 | 33 (63.5) | 19 (36.5) | |||
Multivariate analysis b: Dose delay Objective variable (0: absence of delay, 1: presence of delay) | Parameter estimate | Standard error | Odds ratio | p value | ||
OR | 95% CI | |||||
Hemoglobin (≥ 12 g/dL, < 12 g/dL) | 0.8496 | 0.2801 | 2.339 | 1.351, 4.050 | 0.0024 |