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Table 3 Correlations between angiogenesis-related biomarkers and clinical tumor characteristics (n = 75)

From: Assessing tumor angiogenesis using dynamic contrast-enhanced integrated magnetic resonance-positron emission tomography in patients with non-small-cell lung cancer

(mean ± standard deviation)
p-value
Sex Tumor stage* Histology EGFR Mutation# ALK/ROS1 Rearrangement
Male Female Stage I / II Stage III / IV Adenocarcinoma Non-Adenocarcinoma Found Not found Found Not found
VEGF-A (pg/mL) 326 ± 353 192 ± 231 148 ± 138 318 ± 349 268 ± 309 313 ± 361 254 ± 317 293 ± 326 389 ± 601 275 ± 311
0.053 0.004 0.632 0.621 0.774
Angiogenin (ng/mL) 539 ± 172 491 ± 180 473 ± 111 537 ± 188 504 ± 178 577 ± 160 430 ± 161 571 ± 1 64 735 ± 203 513 ± 170
0.174 0.091 0.102 0.061 0.196
Angiopoietin-1 (ng/mL) 49 ± 39 32 ± 23 43 ± 31 44 ± 37 38 ± 31 57 ± 44 35 ± 30 47 ± 37 53 ± 44 43 ± 35
0.055 0.931 0.095 0.139 0.739
MTV (cm3) 56 ± 61 30 ± 46 12 ± 17 57 ± 61 30 ± 38 96 ± 74 32 ± 37 60 ± 62 82 ± 71 45 ± 57
0.065 < 0.001 0.108 0.139 0.469
SUVmax 15 ± 8 12 ± 6 9 ± 6 15 ± 7 13 ± 7 18 ± 8 12 ± 7 15 ± 7 10 ± 6 14 ± 8
0.070 0.101 0.112 0.156 0.355
ADC (10− 6 mm2/sec) 1056 ± 296 1137 ± 324 1145 ± 499 876 ± 236 1122 ± 321 975 ± 231 1077 ± 321 1088 ± 301 1064 ± 375 1085 ± 306
0.293 0.190 0.059 0.883 0.931
Ktrans (10− 3 min− 1) 392 ± 556 197 ± 333 283 ± 430 464 ± 675 332 ± 556 302 ± 265 401 ± 676 284 ± 371 633 ± 1011 312 ± 474
0.063 0.310 0.754 0.420 0.638
kep (10− 3 min− 1) 1484 ± 1350 1062 ± 1300 935 ± 532 1455 ± 779 1211 ± 1337 1710 ± 1310 1066 ± 931 1482 ± 1501 2689 ± 3436 1281 ± 1207
0.193 0.029 0.163 0.144 0.552
ve (10− 3) 206 ± 192 144 ± 83 286 ± 280 155 ± 97 188 ± 185 176 ± 85 239 ± 253 156 ± 79 135 ± 111 187 ± 167
0.052 0.173 0.722 0.115 0.513
vp (10− 3) 121 ± 99 117 ± 50 114 ± 74 121 ± 88 119 ± 92 120 ± 60 139 ± 118 109 ± 59 75 ± 39 121 ± 86
0.830 0.729 0.984 0.242 0.159
iAUC60 (10− 3) 378 ± 412 266 ± 135 511 ± 622 289 ± 187 350 ± 393 307 ± 127 458 ± 536 276 ± 150 300 ± 285 341 ± 349
0.086 0.165 0.471 0.102 0.831
  1. Abbreviations: MTV = metabolic tumor volume; SUVmax = maximum standardized uptake value; kep = reverse reflux rate constant; Ktrans = volume transfer constant; vp = blood plasma volume fraction; ve = extracellular extravascular volume fraction; ADC = apparent diffusion coefficient; iAUC60 = initial area under the time-to-signal intensity curve at 60 s post enhancement
  2. * Tumor stage was classified by the American Joint Committee on Cancer 8th edition
  3. # EGFR mutation was defined as the presence of an EGFR exon19del or L858R mutation in tumor genomic DNA
  4. † Anaplastic lymphoma kinase (ALK)/c-ros oncogene 1 (ROS1) rearrangement was defined as the presence of an ALK or ROS1 rearrangement in tumor genomic DNA
  5. Significance was tested using Student’s t-test
  6. P-values < 0.05 were considered statistically significant
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