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Fig. 6 | BMC Cancer

Fig. 6

From: Extracellular vesicles-derived microRNA-222 promotes immune escape via interacting with ATF3 to regulate AKT1 transcription in colorectal cancer

Fig. 6

ATF3 interacts with AKT1 in CRC cells. a, ATF3 expression in CRC cells after ATF3 downregulation determined by RT-qPCR; b, quantification of genes in CRC cells after si-ATF3 assessed by RT-qPCR; c, possible binding sites for ATF3 and AKT1 predicted by JASPAR (http://jaspar.binf.ku.dk/); d, the binding of AKT1 and ATF3 validated by ChIP experiments; e, AKT1 expression in CRC cells after co-culture or transfection determined by RT-qPCR; f, the association of AKT1 with ATF3 expression in CRC predicted by TCGA database. Two-way ANOVA was utilized to analyze data among multiple groups, followed by Tukey’s post hoc test

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