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Fig. 4 | BMC Cancer

Fig. 4

From: Extracellular vesicles-derived microRNA-222 promotes immune escape via interacting with ATF3 to regulate AKT1 transcription in colorectal cancer

Fig. 4

ATF3 is a downstream target of miR-222 in CRC cells. a, microarray analysis of mRNA expression changes in CRC cells before and after EVs treatment using R (Version 3.6.3, ww.r-project.org); b, the target genes of miR-222 in CRC depicted by Venn map; c, the targeting relationship between miR-222 and ATF3 verified by dual-luciferase assay; d, the association of miR-222 with ATF3 expression in CRC predicted by TCGA database; e, changes in ATF3 expression in CRC cells after co-culture determined by RT-qPCR; f, mRNA expression of ATF3 in cells measured by RT-qPCR; g, mRNA expression of ATF3 in cells after co-transfection analyzed by RT-qPCR. Two-way ANOVA was utilized to analyze data among multiple groups, followed by Tukey’s post hoc test

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BMC Cancer

ISSN: 1471-2407

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