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Fig. 1 | BMC Cancer

Fig. 1

From: Extracellular vesicles-derived microRNA-222 promotes immune escape via interacting with ATF3 to regulate AKT1 transcription in colorectal cancer

Fig. 1

MSC-EVs induce miR-222 expression in CRC cells. a, differentially expressed miRNAs after MSC-EVs treatment of SW480 and HCT116 cells using R (Version 3.6.3, ww.r-project.org); b, miR-222 expression in MSCs-EVs and in MSCs-supernatant examined by RT-qPCR; c, validation of miR-222 mimic transfection by RT-qPCR; d, detection of MSC to affect CRC cells via exosomes by Transwell co-culture system; e, immunofluorescence detection of cy3-tagged miR-222 mimic fragment in CRC cells; f, miR-222 expression in CRC and normal colonic cells detected by RT-qPCR; g, pre-miR-222 expression in cells detected by RT-qPCR. Measurement data were presented as mean ± SD. Two-way ANOVA was utilized to analyze data among multiple groups, followed by Tukey’s post hoc test

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