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Table 4 Variables associated with DFS according to Cox proportional hazards regression models

From: High vimentin expression with E-cadherin expression loss predicts a poor prognosis after resection of grade 1 and 2 pancreatic neuroendocrine tumors

Variables Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P
Sex    0.040    0.735
 Male Reference    Reference   
 Female 2.052 1.035–4.068   NA NA  
Age, years    0.146    
  ≤ 60 Reference      
  > 60 NA NA     
Symptoms    0.039    0.287
 Absent Reference    Reference   
 Present 2.302 1.042–5.086   NA NA  
Tumor size, cm    0.032    0.572
  ≤ 2 Reference    Reference   
  > 2 2.306 1.076–4.940   NA NA  
Tumor location    0.869    
 Head/uncinate/neck Reference      
 Body/tail NA NA     
T-stage    0.039    0.498
 T1–2 Reference    Reference   
 T3–4 2.102 1.040–4.249   NA NA  
Perineural invasion    0.030    0.331
 Absent Reference    Reference   
 Present 2.665 1.099–6.462   NA NA  
LN metastasis    < 0.001    0.390
 Absent Reference    Reference   
 Present 5.787 2.857–11.724   NA NA  
Distant metastasis    < 0.001    < 0.001
 Absent Reference    Reference   
 Present 25.166 11.112–56.996   6.295 2.385–16.617  
WHO classification    < 0.001    0.003
 Grade 1 Reference    Reference   
 Grade 2 6.014 2.487–14.541   4.106 1.601–10.528  
AJCC stage    < 0.001    0.004
 I-II Reference    Reference   
 III-IV 11.475 5.773–22.811   3.474 1.485–8.126  
EMT markers    < 0.001    < 0.001
 Other group Reference    Reference   
 High vimentin and lost E-cadherin 9.836 4.904–19.724   6.565 3.180–13.553  
  1. DFS Disease-free survival, pNETs Pancreatic neuroendocrine tumors, LN Lymph node, AJCC American Joint Committee on Cancer, EMT Epithelial-mesenchymal transition
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