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Table 3 Variables associated with OS according to Cox proportional hazards regression models

From: High vimentin expression with E-cadherin expression loss predicts a poor prognosis after resection of grade 1 and 2 pancreatic neuroendocrine tumors

Variables Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P
Sex    0.106    
 Male Reference      
 Female NA NA     
Age, years    0.097    
  ≤ 60 Reference      
  > 60 NA NA     
Tumor size, cm    0.575    
  ≤ 2 Reference      
  > 2 NA NA     
Symptoms    0.039    0.168
 Absent Reference    Reference   
 Present 4.768 1.084–20.982   NA NA  
Tumor location    0.424    
 Head/uncinate/neck Reference      
 Body/tail NA NA     
T-stage    0.12    
 T1–2 Reference      
 T3–4 NA NA     
Perineural invasion    0.019    0.430
 Absent Reference    Reference   
 Present 3.870 1.246–12.023   NA NA  
LN metastasis    < 0.001    0.784
 Absent Reference    Reference   
 Present 11.916 4.433–32.028   NA NA  
Distant metastasis    < 0.001    0.690
 Absent Reference    Reference   
 Present 10.102 3.252–31.380   NA NA  
WHO classification    0.010    0.540
 Grade 1 Reference    Reference   
 Grade 2 5.253 1.496–18.443   NA NA  
AJCC stage    < 0.001    < 0.001
 I-II Reference    Reference   
 III-IV 18.602 5.996–57.709   8.646 2.645–28.261  
EMT markers    < 0.001    < 0.001
 Other group Reference    Reference   
High vimentin and lost E-cadherin expression group 20.888 5.951–73.318   10.388 2.794–38.625  
  1. OS Overall survival, pNETs Pancreatic neuroendocrine tumors, LN Lymph node, AJCC American Joint Committee on Cancer, EMT Epithelial-mesenchymal transition
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