High vimentin expression with E-cadherin expression loss predicts a poor prognosis after resection of grade 1 and 2 pancreatic neuroendocrine tumors

Table 2 Associations between vimentin and E-cadherin coexpression and other clinicopathological factors in pNETs

Variable	Total, n	Vimentin and E-cadherin expression pattern, n
Variable	Total, n	High vimentin and lost E-cadherin	Other	P
Age, years				0.291
≤ 60	156	26	130
> 60	71	16	55
Sex				0.390
Male	100	21	79
Female	127	21	106
Symptoms				0.407
Absent	94	15	79
Present	133	27	106
Tumor size, cm				0.107
≤ 2	101	14	87
> 2	126	28	98
Tumor location				0.505
Head/uncinate/neck	103	21	82
Body/tail	124	21	103
T-stage				0.769
T1–2	180	34	146
T3–4	47	8	39
LN metastasis				< 0.001
Absent	203	30	173
Present	24	12	12
Distant metastasis				0.003
Absent	218	37	181
Present	9	5	4
Perineural invasion				0.034
Absent	204	34	170
Present	23	8	15
WHO classification				0.111
Grade 1	117	17	100
Grade 2	110	25	85
AJCC stage				< 0.001
I-II	193	26	167
III-IV	34	16	18

pNETs Pancreatic neuroendocrine tumors, LN Lymph node, AJCC American Joint Committee on Cancer

ISSN: 1471-2407