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Table 1 Patient demographics and clinical characteristics

From: Co-expression of SOX2 and HR-HPV RISH predicts poor prognosis in small cell neuroendocrine carcinoma of the uterine cervix

  SOX2 P16INK4A HR-HPV RISH
Characteristic n Low High P n Neg. Pos. P n Neg. Pos. P
Age (years)     0.392     0.364     0.501
 <  44 40 16 24   40 4 36   40 8 32  
 ≥ 44 48 15 33   48 8 40   48 7 41  
HPV DNA (pg/ml)     0.983     0.514     0.028
 <  1 3 1 2   3 0 3   3 2 1  
 ≥ 1 56 19 37   56 7 49   56 9 47  
FIGO stage     0.178     0.816     0.021
 ≤ IIA 79 26 53   79 11 68   79 11 68  
 ≥ IIB 9 5 4   9 1 8   9 4 5  
Pre-operative Chemotherapy     0.084     0.681     0.007
 No 56 16 40   56 7 49   56 5 51  
 Yes 32 15 17   32 5 27   32 10 22  
Post-operative Chemotherapy     0.661     0.416     0.353
 No 4 1 3   4 0 4   4 0 4  
 Yes 84 30 54   84 12 72   84 15 69  
Post-operative Radiotherapy     0.120     0.109     0.826
 No 33 15 18   33 2 31   33 6 27  
 Yes 55 16 39   55 10 45   55 9 46  
Pathological type     0.699     0.473     0.014
 SCNEC -alone 66 24 42   66 10 56   66 15 51  
 SCNEC -mix 22 7 15   22 2 20   22 0 22  
Tumor size (cm)     0.358     0.112     0.896
 < 2 11 6 5   11 3 8   11 2 9  
 2–4 40 13 27   40 7 33   40 6 34  
 ≥4 37 12 25   37 2 35   37 7 30  
Stromal invasion     0.948     0.225     0.281
 < 1/2 28 10 18   28 2 26   28 3 25  
 ≥1/2 60 21 39   60 10 50   60 12 48  
Endometrial invasion     0.178     0.816     0.170
 No 79 26 53   79 11 68   79 12 67  
 Yes 9 5 4   9 1 8   9 3 6  
Parametrium invasion     0.737     0.182     0.792
 No 78 27 51   78 12 66   78 13 65  
 Yes 10 4 6   10 0 10   10 2 8  
CIN     0.866     0.970     0.241
 No 73 26 47   73 10 63   73 14 59  
 Yes 15 5 10   15 2 13   15 1 14  
LNM     0.293     0.566     0.283
 No 52 16 36   52 8 44   52 7 45  
 Yes 36 15 21   36 4 32   36 8 28  
Nerve invasion     0.835     0.921     0.107
 No 67 24 43   67 9 58   67 9 58  
 Yes 21 7 14   21 3 15   21 6 15  
LVI     0.023     0.176     0.973
 No 29 15 14   29 6 23   29 5 24  
 Yes 59 16 43   59 6 53   59 10 49  
Relapse     0.023     0.297     0.027
 No 54 24 30   54 9 45   54 13 41  
 Yes 34 7 27   34 3 31   34 2 32  
N-marker     0.900     0.069     0.021
 ≤2 + 9 3 6   9 3 6   9 4 5  
 > 2 + 79 28 51   79 9 70   79 11 68  
MMR     0.737     0.182     0.792
 pMMR 78 27 51   78 12 66   78 13 65  
 dMMR 10 4 6   10 0 10   10 2 8  
Ki67(%)     0.105     0.005     0.154
 < 60 13 2 11   13 5 8   13 4 9  
 ≥60 75 29 46   75 7 68   75 11 64  
  1. CIN Cervical Intraepithelial Neoplasia, LNM Lymph Node Metastasis, LVI Lymphatic Vessel Invasion, N-marker Neuroendocrine-marker, MMR Mismatch Repair