| SOX2 | P16INK4A | HR-HPV RISH | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Characteristic | n | Low | High | P | n | Neg. | Pos. | P | n | Neg. | Pos. | P |
Age (years) | Â | Â | Â | 0.392 | Â | Â | Â | 0.364 | Â | Â | Â | 0.501 |
 <  44 | 40 | 16 | 24 |  | 40 | 4 | 36 |  | 40 | 8 | 32 |  |
 ≥ 44 | 48 | 15 | 33 |  | 48 | 8 | 40 |  | 48 | 7 | 41 |  |
HPV DNA (pg/ml) | Â | Â | Â | 0.983 | Â | Â | Â | 0.514 | Â | Â | Â | 0.028 |
 <  1 | 3 | 1 | 2 |  | 3 | 0 | 3 |  | 3 | 2 | 1 |  |
 ≥ 1 | 56 | 19 | 37 |  | 56 | 7 | 49 |  | 56 | 9 | 47 |  |
FIGO stage | Â | Â | Â | 0.178 | Â | Â | Â | 0.816 | Â | Â | Â | 0.021 |
 ≤ IIA | 79 | 26 | 53 |  | 79 | 11 | 68 |  | 79 | 11 | 68 |  |
 ≥ IIB | 9 | 5 | 4 |  | 9 | 1 | 8 |  | 9 | 4 | 5 |  |
Pre-operative Chemotherapy | Â | Â | Â | 0.084 | Â | Â | Â | 0.681 | Â | Â | Â | 0.007 |
 No | 56 | 16 | 40 |  | 56 | 7 | 49 |  | 56 | 5 | 51 |  |
 Yes | 32 | 15 | 17 |  | 32 | 5 | 27 |  | 32 | 10 | 22 |  |
Post-operative Chemotherapy | Â | Â | Â | 0.661 | Â | Â | Â | 0.416 | Â | Â | Â | 0.353 |
 No | 4 | 1 | 3 |  | 4 | 0 | 4 |  | 4 | 0 | 4 |  |
 Yes | 84 | 30 | 54 |  | 84 | 12 | 72 |  | 84 | 15 | 69 |  |
Post-operative Radiotherapy | Â | Â | Â | 0.120 | Â | Â | Â | 0.109 | Â | Â | Â | 0.826 |
 No | 33 | 15 | 18 |  | 33 | 2 | 31 |  | 33 | 6 | 27 |  |
 Yes | 55 | 16 | 39 |  | 55 | 10 | 45 |  | 55 | 9 | 46 |  |
Pathological type | Â | Â | Â | 0.699 | Â | Â | Â | 0.473 | Â | Â | Â | 0.014 |
 SCNEC -alone | 66 | 24 | 42 |  | 66 | 10 | 56 |  | 66 | 15 | 51 |  |
 SCNEC -mix | 22 | 7 | 15 |  | 22 | 2 | 20 |  | 22 | 0 | 22 |  |
Tumor size (cm) | Â | Â | Â | 0.358 | Â | Â | Â | 0.112 | Â | Â | Â | 0.896 |
 < 2 | 11 | 6 | 5 |  | 11 | 3 | 8 |  | 11 | 2 | 9 |  |
 2–4 | 40 | 13 | 27 |  | 40 | 7 | 33 |  | 40 | 6 | 34 |  |
 ≥4 | 37 | 12 | 25 |  | 37 | 2 | 35 |  | 37 | 7 | 30 |  |
Stromal invasion | Â | Â | Â | 0.948 | Â | Â | Â | 0.225 | Â | Â | Â | 0.281 |
 < 1/2 | 28 | 10 | 18 |  | 28 | 2 | 26 |  | 28 | 3 | 25 |  |
 ≥1/2 | 60 | 21 | 39 |  | 60 | 10 | 50 |  | 60 | 12 | 48 |  |
Endometrial invasion | Â | Â | Â | 0.178 | Â | Â | Â | 0.816 | Â | Â | Â | 0.170 |
 No | 79 | 26 | 53 |  | 79 | 11 | 68 |  | 79 | 12 | 67 |  |
 Yes | 9 | 5 | 4 |  | 9 | 1 | 8 |  | 9 | 3 | 6 |  |
Parametrium invasion | Â | Â | Â | 0.737 | Â | Â | Â | 0.182 | Â | Â | Â | 0.792 |
 No | 78 | 27 | 51 |  | 78 | 12 | 66 |  | 78 | 13 | 65 |  |
 Yes | 10 | 4 | 6 |  | 10 | 0 | 10 |  | 10 | 2 | 8 |  |
CIN | Â | Â | Â | 0.866 | Â | Â | Â | 0.970 | Â | Â | Â | 0.241 |
 No | 73 | 26 | 47 |  | 73 | 10 | 63 |  | 73 | 14 | 59 |  |
 Yes | 15 | 5 | 10 |  | 15 | 2 | 13 |  | 15 | 1 | 14 |  |
LNM | Â | Â | Â | 0.293 | Â | Â | Â | 0.566 | Â | Â | Â | 0.283 |
 No | 52 | 16 | 36 |  | 52 | 8 | 44 |  | 52 | 7 | 45 |  |
 Yes | 36 | 15 | 21 |  | 36 | 4 | 32 |  | 36 | 8 | 28 |  |
Nerve invasion | Â | Â | Â | 0.835 | Â | Â | Â | 0.921 | Â | Â | Â | 0.107 |
 No | 67 | 24 | 43 |  | 67 | 9 | 58 |  | 67 | 9 | 58 |  |
 Yes | 21 | 7 | 14 |  | 21 | 3 | 15 |  | 21 | 6 | 15 |  |
LVI | Â | Â | Â | 0.023 | Â | Â | Â | 0.176 | Â | Â | Â | 0.973 |
 No | 29 | 15 | 14 |  | 29 | 6 | 23 |  | 29 | 5 | 24 |  |
 Yes | 59 | 16 | 43 |  | 59 | 6 | 53 |  | 59 | 10 | 49 |  |
Relapse | Â | Â | Â | 0.023 | Â | Â | Â | 0.297 | Â | Â | Â | 0.027 |
 No | 54 | 24 | 30 |  | 54 | 9 | 45 |  | 54 | 13 | 41 |  |
 Yes | 34 | 7 | 27 |  | 34 | 3 | 31 |  | 34 | 2 | 32 |  |
N-marker | Â | Â | Â | 0.900 | Â | Â | Â | 0.069 | Â | Â | Â | 0.021 |
 ≤2 + | 9 | 3 | 6 |  | 9 | 3 | 6 |  | 9 | 4 | 5 |  |
 > 2 + | 79 | 28 | 51 |  | 79 | 9 | 70 |  | 79 | 11 | 68 |  |
MMR | Â | Â | Â | 0.737 | Â | Â | Â | 0.182 | Â | Â | Â | 0.792 |
 pMMR | 78 | 27 | 51 |  | 78 | 12 | 66 |  | 78 | 13 | 65 |  |
 dMMR | 10 | 4 | 6 |  | 10 | 0 | 10 |  | 10 | 2 | 8 |  |
Ki67(%) | Â | Â | Â | 0.105 | Â | Â | Â | 0.005 | Â | Â | Â | 0.154 |
 < 60 | 13 | 2 | 11 |  | 13 | 5 | 8 |  | 13 | 4 | 9 |  |
 ≥60 | 75 | 29 | 46 |  | 75 | 7 | 68 |  | 75 | 11 | 64 |  |