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Fig. 6 | BMC Cancer

Fig. 6

From: RGD4C peptide mediates anti-p21Ras scFv entry into tumor cells and produces an inhibitory effect on the human colon cancer cell line SW480

Fig. 6

(a and b) A TUNEL assay was used to detect SW480 cell apoptosis after treatment with RGD4C-p21Ras-scFv. More apoptotic cells were found in the RGD4C-scFv and RGD4C-linker-scFv groups than in the anti-p21Ras scFv group (green: apoptotic cell, blue: nucleus) (P < 0.05). (c) There was more green fluorescence were observed in the RGD4C-scFv and RGD4C-scFv+CQ groups of SW480, but other groups showed rarely green fluorescence signal. (d) More apoptotic cells were found in RGD4C-scFv+CQ compared with RGD4C-scFv group of SW480. (e and f) There were rarely green fluorescence observed with CACO-2 and CCD841 cells no matter RGD4C-scFv, RGD4C-scFv+CQ, RGD4C-EGFP and PBS groups. It implied that RGD4C-scFv did not induce CACO-2 and CCD841 cells apoptosis. Data of groups are presented as the mean ± S.D. *Significantly different from the control group (P < 0.05). **P < 0.01 vs controls

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BMC Cancer

ISSN: 1471-2407

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