TY - JOUR AU - Huang, Chen-Chen AU - Liu, Fang-Rui AU - Feng, Qiang AU - Pan, Xin-Yan AU - Song, Shu-Ling AU - Yang, Ju-Lun PY - 2021 DA - 2021/03/25 TI - RGD4C peptide mediates anti-p21Ras scFv entry into tumor cells and produces an inhibitory effect on the human colon cancer cell line SW480 JO - BMC Cancer SP - 321 VL - 21 IS - 1 AB - We prepared an anti-p21Ras scFv which could specifically bind with mutant and wild-type p21Ras. However, it cannot penetrate the cell membrane, which prevents it from binding to p21Ras in the cytoplasm. Here, the RGD4C peptide was used to mediate the scFv penetration into tumor cells and produce antitumor effects. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-021-08056-4 DO - 10.1186/s12885-021-08056-4 ID - Huang2021 ER -