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Table 1 Medication or Medication Classes Identified by Protocol Guidance as Drug-drug Interactions

From: Drug-drug interactions in subjects enrolled in SWOG trials of oral chemotherapy

Trial

Exclusion

Avoid

Caution

S0711

Acid suppression therapy (PPI, H2RA, antacida)

CYP3A4 inhibitors, CYP3A4 inducers, antiplatelet agents, anticoagulants

QT prolonging agents

S0528

Acid suppression therapy (PPI, H2RA, antacida)

CYP3A4 inhibitors, CYP3A4 inducers

Warfarin

  1. PPI proton pump inhibitor, H2RA histamine H2 antagonists
  2. aantacids were permitted for use if administration separated by 2 h from dasatinib or 1 h from lapatinib per the protocols