Table 4 Univariate analyses of the prognostic factors for disease-free survival (DFS) and cancer specific survival (CSS)
Variable | n | 5-year DFS (%) | HR | 95% CI | p | 5-year CSS (%) | HR | 95% CI | p |
|---|---|---|---|---|---|---|---|---|---|
Age, years | 0.463 | 0.318 | |||||||
≤ 65 | 100 | 72.0 | 1.000 | 0.698–2.204 | 91.0 | 1.000 | 0.634–4.079 | ||
> 65 | 57 | 66.7 | 1.240 | 87.7 | 1.608 | ||||
Gender | 0.808 | 0.412 | |||||||
Female | 86 | 70.9 | 1.000 | 0.612–1.880 | 91.9 | 1.000 | 0.583–3.742 | ||
Male | 71 | 69.0 | 1.072 | 87.3 | 1.476 | ||||
Tumour location | 0.052 | 0.768 | |||||||
Colon | 83 | 75.9 | 1.000 | 0.994–3.110 | 90.4 | 1.000 | 0.456–2.896 | ||
Rectum | 74 | 63.5 | 1.759 | 89.2 | 1.149 | ||||
Preoperative CEA level | 0.957 | 0.776 | |||||||
≤ 5 ng/ml | 89 | 69.7 | 1.000 | 0.541–1.693 | 89.9 | 1.000 | 0.445–2.960 | ||
> 5 ng/ml | 68 | 70.6 | 0.957 | 89.7 | 1.148 | ||||
Tumour size | 0.632 | 0.789 | |||||||
≤ 5 cm | 62 | 66.1 | 1.000 | 0.496–1.531 | 88.7 | 1.000 | 0.340–2.67 | ||
> 5 cm | 95 | 72.6 | 0.872 | 90.5 | 0.878 | ||||
Histological type | 0.605 | 0.678 | |||||||
Well- or moderately differentiated | 150 | 70.7 | 1.000 | 0.423–4.378 | 90.0 | 1.000 | 0.204–11.534 | ||
Poorly differentiated | 7 | 57.1 | 1.361 | 85.7 | 1.534 | ||||
Tumour invasion | 0.906 | 0.871 | |||||||
< T3 | 27 | 70.4 | 1.000 | 0.712–1.467 | 92.6 | 1.000 | 0.321–3.827 | ||
T3≤ | 130 | 70.0 | 1.022 | 89.2 | 1.108 | ||||
Lymph node status | 0.049 | 0.993 | |||||||
N1 | 107 | 73.6 | 1.000 | 1.003–3.311 | 88.4 | 1.000 | 0.572–1.739 | ||
N2 | 36 | 58.3 | 1.822 | 94.4 | 0.997 | ||||
Adjuvant chemotherapy | 0.717 | 0.122 | |||||||
No | 32 | 71.9 | 1.000 | 0.554–2.361 | 87.5 | 1.000 | 0.157–1.244 | ||
Yes | 125 | 69.6 | 1.144 | 90.4 | 0.442 | ||||
TMEM180 expression | 0.328 | 0.036 | |||||||
Low | 92 | 73.9 | 1.000 | 0.755–2.320 | 94.6 | 1.000 | 1.071–7.603 | ||
High | 65 | 64.6 | 1.323 | 83.1 | 2.853 |