Table 4 Predictive target genes of miR-221-3p with GO analysis
GO ID | GO term | Count (%) | Gene symbol | p-value |
|---|---|---|---|---|
Cellular component | ||||
 GO:0015629 | actin cytoskeleton | 12 | AMOT, ANXA1, CGNL1, COBL, KALRN, MYL2,MYZAP, SCIN, SORBS1, SORBS2, SYNPO2, XIRP2 | 6.22E-06 |
 GO:0030017 | sarcomere | 7 | KLHL41, LDB3, MYL2, MYZAP, SORBS2, SYNPO2, XIRP2 | 6.06E-05 |
 GO:0044449 | contractile fiber part | 7 | KLHL41, LDB3, MYL2, MYZAP, SORBS2, SYNPO2, XIRP2 | 1.12E-04 |
 GO:0030016 | myofibril | 7 | KLHL41, LDB3, MYL2, MYZAP, SORBS2, SYNPO2, XIRP2 | 1.32E-04 |
 GO:0043292 | contractile fiber | 7 | KLHL41, LDB3, MYL2, MYZAP, SORBS2, SYNPO2, XIRP2 | 1.90E-04 |
 GO:0030018 | Z disc | 5 | LDB3, MYZAP, SORBS2, SYNPO2, XIRP2 | 3.44E-04 |
 GO:0031674 | I band | 5 | LDB3, MYZAP, SORBS2, SYNPO2, XIRP2 | 5.21E-04 |
 GO:0033017 | sarcoplasmic reticulum membrane | 3 | ATP2A1, KLHL41, TRDN | 1.11E-03 |
Molecular function | ||||
 GO:0070330 | aromatase activity | 4 | CYP2F1, CYP3A5, CYP4B1, CYP4X1 | 6.04E-06 |
 GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 4 | CYP2F1, CYP3A5, CYP4B1, CYP4X1 | 8.86E-06 |
 GO:0048037 | cofactor binding | 12 | ALDH1A1, CRYM, CYP3A5, CYP4B1, CYP4X1, FMO2, GPD1, GPT2, HPGD, MAOB, MB, STEAP4 | 9.13E-06 |
 GO:0019825 | oxygen binding | 4 | CYP2F1, CYP3A5, CYP4B1, MB | 1.73E-05 |
 GO:0050662 | coenzyme binding | 8 | ALDH1A1, CRYM, FMO2, GPD1, GPT2, HPGD, MAOB, STEAP4 | 1.30E-04 |
 GO:0004497 | monooxygenase activity | 5 | CYP2F1, CYP3A5, CYP4B1, CYP4X1, FMO2 | 1.46E-04 |
 GO:0051393 | alpha-actinin binding | 3 | LDB3, SYNPO2, XIRP2 | 2.37E-04 |
 GO:0020037 | heme binding | 5 | CYP3A5, CYP4B1, CYP4X1, MB, STEAP4 | 3.88E-04 |
 GO:0046906 | tetrapyrrole binding | 5 | CYP3A5, CYP4B1, CYP4X1, MB, STEAP4 | 5.87E-04 |
 GO:0042805 | actinin binding | 3 | LDB3, SYNPO2, XIRP2 | 6.30E-04 |
 GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 5 | CYP2F1, CYP3A5, CYP4B1, CYP4X1, FMO2 | 1.24E-03 |
 GO:0033130 | acetylcholine receptor binding | 2 | LYNX1, PSCA | 1.47E-03 |
 GO:0016722 | oxidoreductase activity, oxidizing metal ions | 2 | CP, STEAP4 | 2.14E-03 |
 GO:0030674 | protein binding, bridging | 5 | MAPT, SORBS1, SORBS2, SYNPO2, TRDN | 2.20E-03 |