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Table 4 Predictive target genes of miR-221-3p with GO analysis

From: Bioinformatics analysis of the expression and role of microRNA-221-3p in head and neck squamous cell carcinoma

GO ID GO term Count (%) Gene symbol p-value
Cellular component
 GO:0015629 actin cytoskeleton 12 AMOT, ANXA1, CGNL1, COBL, KALRN, MYL2,MYZAP, SCIN, SORBS1, SORBS2, SYNPO2, XIRP2 6.22E-06
 GO:0030017 sarcomere 7 KLHL41, LDB3, MYL2, MYZAP, SORBS2, SYNPO2, XIRP2 6.06E-05
 GO:0044449 contractile fiber part 7 KLHL41, LDB3, MYL2, MYZAP, SORBS2, SYNPO2, XIRP2 1.12E-04
 GO:0030016 myofibril 7 KLHL41, LDB3, MYL2, MYZAP, SORBS2, SYNPO2, XIRP2 1.32E-04
 GO:0043292 contractile fiber 7 KLHL41, LDB3, MYL2, MYZAP, SORBS2, SYNPO2, XIRP2 1.90E-04
 GO:0030018 Z disc 5 LDB3, MYZAP, SORBS2, SYNPO2, XIRP2 3.44E-04
 GO:0031674 I band 5 LDB3, MYZAP, SORBS2, SYNPO2, XIRP2 5.21E-04
 GO:0033017 sarcoplasmic reticulum membrane 3 ATP2A1, KLHL41, TRDN 1.11E-03
Molecular function
 GO:0070330 aromatase activity 4 CYP2F1, CYP3A5, CYP4B1, CYP4X1 6.04E-06
 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4 CYP2F1, CYP3A5, CYP4B1, CYP4X1 8.86E-06
 GO:0048037 cofactor binding 12 ALDH1A1, CRYM, CYP3A5, CYP4B1, CYP4X1, FMO2, GPD1, GPT2, HPGD, MAOB, MB, STEAP4 9.13E-06
 GO:0019825 oxygen binding 4 CYP2F1, CYP3A5, CYP4B1, MB 1.73E-05
 GO:0050662 coenzyme binding 8 ALDH1A1, CRYM, FMO2, GPD1, GPT2, HPGD, MAOB, STEAP4 1.30E-04
 GO:0004497 monooxygenase activity 5 CYP2F1, CYP3A5, CYP4B1, CYP4X1, FMO2 1.46E-04
 GO:0051393 alpha-actinin binding 3 LDB3, SYNPO2, XIRP2 2.37E-04
 GO:0020037 heme binding 5 CYP3A5, CYP4B1, CYP4X1, MB, STEAP4 3.88E-04
 GO:0046906 tetrapyrrole binding 5 CYP3A5, CYP4B1, CYP4X1, MB, STEAP4 5.87E-04
 GO:0042805 actinin binding 3 LDB3, SYNPO2, XIRP2 6.30E-04
 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 5 CYP2F1, CYP3A5, CYP4B1, CYP4X1, FMO2 1.24E-03
 GO:0033130 acetylcholine receptor binding 2 LYNX1, PSCA 1.47E-03
 GO:0016722 oxidoreductase activity, oxidizing metal ions 2 CP, STEAP4 2.14E-03
 GO:0030674 protein binding, bridging 5 MAPT, SORBS1, SORBS2, SYNPO2, TRDN 2.20E-03
  1. Notes: GO: Gene Ontology