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Table 2 The correlation between miR-221-3p expression levels and clinic characteristics based on TCGA database

From: Bioinformatics analysis of the expression and role of microRNA-221-3p in head and neck squamous cell carcinoma

Clinicopathological features

Terms

n

Mean ± SD

p-value

Unpaired tissue

Normal

44

8.16 ± 0.64

0.001

HNSCC

480

8.55 ± 0.78

 

Sex

Male

383

8.45 ± 0.79

0.001

Female

141

8.71 ± 0.68

 

Age

< 60

234

8.50 ± 0.76

0.559

> = 60

290

8.54 ± 0.78

 

lymphovascular invasion

NO

232

8.54 ± 0.81

0.429

YES

292

8.49 ± 0.75

 

Neoplasm histologic grade

G1-G2

371

8.49 ± 0.73

0.260

G3-G4

156

8.58 ± 0.82

 

M stage

M0

498

8.51 ± 0.78

0.967

M1

29

8.51 ± 0.57

 

N stage

N0

246

8.53 ± 0.76

0.572

N1-N3

281

8.49 ± 0.77

 

Alcohol

NO

164

8.62 ± 0.76

0.047

YES

363

8.48 ± 0.76

 

HPV status

Negative

194

8.41 ± 0.81

0.066

Positive

330

8.55 ± 0.81

 

Perineural invasion

NO

198

8.53 ± 0.81

0.693

YES

329

8.50 ± 0.80

  1. Notes: HNSCC, Head and neck squamous cell carcinoma; T stage, size or direct extent of the primary tumor; N stage, degree of spread to regional lymph nodes; M stage, presence of distant metastasis; SD, standard deviation