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Table 4 Multivariate analysis by adjusted age, sex and T category or N category of the two editions

From: Comparing the 7th and 8th editions of UICC/AJCC staging system for nasopharyngeal carcinoma in the IMRT era

  OS LRRFS DFS
7th edition
 T category HR (95%CI) P-value HR (95%CI) P-value HR (95%CI) P-value
 T1 vs. T2 1.465 (0.350–6.133) 0.601 1.114 (0.352–3.525) 0.855 1.183 (0.450–3.111) 0.733
 T1 vs. T3 0.559 (0.178–1.715) 0.318 1.513 (0.383–5.975) 0.554 0.614 (0.269–1.399) 0.245
 T1 vs. T4 0.212 (0.081–0.558) 0.020 1.583 (0.456–5.502) 0.470 0.305 (0.149–0.625) 0.001
 Overall P <0.001 0.364 <0.001
8th edition
 T category HR (95%CI) P-value HR (95%CI) P-value HR (95%CI) P-value
 T1 vs. T2 1.506 (0.360–6.307) 0.575 1.190 (0.376–3.768) 0.767 1.075 (0.424–2.726) 0.878
 T1 vs. T3 0.343 (0.130–0.908) 0.031 1.470 (0.510–4.238) 0.476 0.487 (0.239–0.996) 0.049
 T1 vs. T4 0.194 (0.065–0.580) 0.003 0.310 (0.030–3.203) 0.326 0.239 (0.100–0.572) 0.001
 Overall P <0.001 0.144 <0.001
  OS DMFS DFS
7th edition
 N category HR (95%CI) P-value HR (95%CI) P-value HR (95%CI) P-value
 N1 vs. N0 0.104 (0.013–0.805) 0.300 0.781 (0.138–4.410) 0.779 0.137 (0.032–0.595) 0.008
 N1 vs. N2 0.862 (0.427–1.743) 0.680 0.580 (0.184–1.823) 0.351 0.944 (0.533–1.671) 0.842
 N1 vs. N3a 1.632 (0.210–12.690) 0.640 0.216 (0.037–1.265) 0.089 0.747 (0.218–2.566) 0.643
 N1 vs. N3b 0.587 (0.188–1.836) 0.360 0.371 (0.066–2.089) 0.261 0.514 (0.215–1.231) 0.135
 Overall P 0.004 0.519 <0.001
8th edition
 N category HR (95%CI) P-value HR (95%CI) P-value HR (95%CI) P-value
 N1 vs. N0 2.095 (1.270–3.457) 0.004 1.722 (0.701–4.231) 0.236 1.700 (0.746–3.877) <0.001
 N1 vs. N2 1.212 (0.592–1.212) 0.599 1.985 (0.629–6.264) 0.242 1.098 (0.612–1.970) 0.754
 N1 vs. N3 1.037 (0.649–1.656) 0.880 1.408 (0.701–2.829) 0.337 1.166 (0.818–1.662) 0.395
 Overall P 0.008 0.316 0.001
  1. Abbreviations: CI Confidence interval. HR Hazard ratio. OS Overall survival. DFS Disease-free survival. LRRFS Locoregional recurrence-free survival. DMFS Distant metastasis-free survival
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