Table 2 GO functional annotation for genes in pink and blue modules
From: Identification of the potential novel biomarkers as susceptibility gene for Wilms tumor
Series | Name | P-value | Adjusted p-value | Z-score | Combined score | Genes |
|---|---|---|---|---|---|---|
GO Celluar Component | spindle midzone (GO:0051233) | 2.19E-14 | 3.41E-12 | −2.19 | 68.75 | TPX2;PRC1;BUB1B;CDCA8;TTK;CDC6;KIF20A;KIF11;AURKB;AURKA |
GO Celluar Component | condensed chromosome kinetochore (GO:0000777) | 3.43E-14 | 3.41E-12 | −1.89 | 58.71 | BUB1B;BIRC5;NCAPD2;BUB1;AURKB;NDC80;SPC25 |
GO Celluar Component | condensed nuclear chromosome kinetochore (GO:0000778) | 3.43E-14 | 3.41E-12 | −1.71 | 53.02 | BUB1B;BIRC5;BUB1;AURKB;NDC80;SPC25;AURKA |
GO Celluar Component | polar microtubule (GO:0005827) | 4.38E-13 | 3.26E-11 | −2.13 | 60.63 | TPX2;CCNB1;SPAG5;PRC1;KIF4A;CDK1;CDC6;KIF11;AURKB;AURKA |
GO Celluar Component | mitotic spindle (GO:0072686) | 5.47E-13 | 3.26E-11 | −2.24 | 63.12 | TPX2;SPAG5;PRC1;CDK1;TTK;KIF20A;KIF11;AURKB;AURKA;MAD2L1 |
GO Celluar Component | mitotic spindle midzone (GO:1990023) | 8.40E-13 | 4.17E-11 | −1.99 | 55.37 | TPX2;SPAG5;CDK1;BUB1B;CDCA8;CDC6;AURKB;AURKA;MAD2L1 |
GO Celluar Component | mitotic spindle microtubule (GO:1990498) | 2.46E-12 | 1.05E-10 | −2.07 | 55.43 | TPX2;SPAG5;PRC1;KIF4A;CDK1;KIF11;AURKB;AURKA;MAD2L1 |
GO Celluar Component | kinetochore microtubule (GO:0005828) | 1.92E-11 | 7.15E-10 | −1.7 | 41.94 | SPAG5;PRC1;KIF4A;CDK1;KIF11;AURKB;AURKA |
GO Biological process | spindle organization (GO:0007051) | 2.68E-11 | 3.42E-09 | −2.63 | 63.98 | RANBP1;SPAG5;TTK;KIF11;AURKB;AURKA |
GO Biological process | sister chromatid cohesion (GO:0007062) | 3.00E-11 | 3.42E-09 | −2.74 | 66.3 | BUB1B;CDCA8;BIRC5;BUB3;BUB1;AURKB;NDC80;SPC25;MAD2L1 |
GO Celluar Component | spindle microtubule (GO:0005876) | 4.08E-11 | 1.35E-09 | −2.24 | 53.52 | TPX2;SPAG5;PRC1;KIF4A;CDK1;TTK;KIF20A;KIF11;AURKB;AURKA |
GO Celluar Component | spindle pole (GO:0000922) | 5.66E-11 | 1.69E-09 | −2.15 | 50.77 | TPX2;CCNB1;PRC1;TTK;CDC6;KIF20A;KIF11;AURKB;AURKA |
GO Celluar Component | spindle pole centrosome (GO:0031616) | 1.05E-10 | 2.86E-09 | −3.37 | 77.48 | RANBP1;PCNA;CDC6;KIF11;AURKB;NDC80;AURKA;KIF15;TPX2;CCNB2;CCNB1;CHEK1;CDK1;DLGAP5 |
GO Biological process | anaphase-promoting complex-dependent catabolic process (GO:0031145) | 2.18E-10 | 1.66E-08 | −2.6 | 57.76 | CCNB1;PTTG1;CDK1;BUB1B;BUB3;AURKB;AURKA;MAD2L1 |
GO Biological process | mitotic cell cycle (GO:0000278) | 3.93E-10 | 2.24E-08 | −2.78 | 60.2 | TPX2;PBK;BUB1B;CDC6;KIF11;NDC80;AURKA;KIF15 |
GO Biological process | mitotic spindle organization (GO:0007052) | 7.06E-10 | 3.22E-08 | −2.88 | 60.61 | CCNB1;TTK;KIF11;NDC80;SPC25;AURKA |
GO Celluar Component | meiotic spindle (GO:0072687) | 7.13E-10 | 1.77E-08 | −1.86 | 39.08 | TPX2;PRC1;TTK;KIF20A;KIF11;AURKB;AURKA |
GO Celluar Component | mitotic spindle pole (GO:0097431) | 3.29E-09 | 7.55E-08 | −2.14 | 41.73 | TPX2;CCNB1;SPAG5;CDK1;CDC6;KIF11;AURKA;MAD2L1 |
GO Biological process | protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) | 6.50E-09 | 2.47E-07 | −2.97 | 56.06 | CCNB1;PTTG1;CDK1;BUB1B;BUB3;AURKB;AURKA;MAD2L1 |
GO Celluar Component | condensed nuclear chromosome outer kinetochore (GO:0000942) | 7.50E-09 | 1.60E-07 | 0.77 | −14.35 | CCNB1;BUB1B;BUB1;NDC80 |
GO Biological process | G2/M transition of mitotic cell cycle (GO:0000086) | 8.39E-09 | 2.73E-07 | −2.75 | 51.19 | TPX2;CCNB2;CCNB1;MELK;CDK1;FOXM1;CDC25C;AURKA |
GO Celluar Component | meiotic spindle midzone (GO:1990385) | 1.36E-08 | 2.70E-07 | −1.25 | 22.56 | BUB1B;CDCA8;CDC6;AURKB;AURKA |
GO Celluar Component | condensed chromosome, centromeric region (GO:0000779) | 1.85E-08 | 3.45E-07 | −1.61 | 28.65 | CDCA8;BIRC5;OIP5;NCAPD2;AURKB;NDC80 |
GO Biological process | DNA replication (GO:0006260) | 5.79E-08 | 0.000001651 | −2.75 | 45.81 | FEN1;CHEK1;CDK1;MCM10;DNA2;CDC6;CDC25C |
GO Biological process | protein sumoylation (GO:0016925) | 9.54E-08 | 0.000002418 | −2.62 | 42.29 | PCNA;TRIM28;CDCA8;BIRC5;SAE1;AURKB |
GO Celluar Component | spindle (GO:0005819) | 1.19E-07 | 0.000002088 | −2.26 | 35.97 | TPX2;CCNB2;PRC1;TTK;KIF20A;KIF11;AURKB;AURKA |
GO Molecular Function | protein kinase binding (GO:0019901) | 4.76E-07 | 0.00004189 | −5.54 | 80.67 | TPX2;CCNB1;PRC1;KIF20A;KIF11;FOXM1;CDC25C;TRIM22;AURKA |
GO Biological process | chromosome segregation (GO:0007059) | 5.15E-07 | 0.00001173 | −2.27 | 32.94 | SPAG5;OIP5;KIF11;NDC80;SPC25 |
GO Celluar Component | centriolar satellite (GO:0034451) | 9.11E-07 | 0.00001507 | −3.18 | 44.17 | CCNB2;RANBP1;CCNB1;PCNA;SPAG5;CHEK1;CDK1;NDC80;AURKA;KIF15 |
GO Biological process | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977) | 0.000001877 | 0.00003609 | −2.51 | 33.14 | CCNB1;PCNA;CDK1;CDC25C;AURKA |
GO Biological process | protein localization to kinetochore (GO:0034501) | 0.0000019 | 0.00003609 | −0.67 | 8.8 | CDK1;BUB1B;AURKB |
GO Celluar Component | centrosome (GO:0005813) | 0.000002228 | 0.00003494 | −3.18 | 41.37 | CCNB2;RANBP1;CCNB1;PCNA;CHEK1;CDK1;DLGAP5;NDC80;AURKA;KIF15 |
GO Celluar Component | condensed nuclear chromosome, centromeric region (GO:0000780) | 2.78E-06 | 4.14E-05 | −1.37 | 17.58 | CHEK1;NCAPD2;AURKB;AURKA |
GO Biological process | attachment of spindle microtubules to kinetochore (GO:0008608) | 0.000002843 | 0.00004986 | −1.09 | 13.89 | BUB3;AURKB;NDC80 |
GO Biological process | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 0.000003956 | 0.00006443 | −2.34 | 29.13 | CCNB1;CDK1;BUB1B;BUB3;MAD2L1 |
GO Celluar Component | chromosome, centromeric outer repeat region (GO:0034507) | 5.24E-06 | 7.10E-05 | −1.08 | 13.07 | CDCA8;BIRC5;OIP5;NDC80 |
GO Celluar Component | chromosome, centromeric region (GO:0000775) | 0.000005243 | 0.00007102 | −1.04 | 12.62 | CDCA8;BIRC5;OIP5;NDC80 |
GO Biological process | positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition (GO:0051437) | 0.000005517 | 0.00008385 | −2.29 | 27.77 | CCNB1;CDK1;BUB1B;BUB3;MAD2L1 |
GO Celluar Component | chromosome, centromeric core domain (GO:0034506) | 0.000005884 | 0.00007623 | −1.13 | 13.61 | CDCA8;BIRC5;OIP5;NDC80 |
GO Celluar Component | centrosomal corona (GO:0031592) | 0.000006456 | 0.00008016 | −3.03 | 36.22 | CCNB2;RANBP1;CCNB1;PCNA;CHEK1;CDK1;NDC80;AURKA;KIF15 |
GO Celluar Component | pericentriolar material (GO:0000242) | 0.000007133 | 0.00008502 | −3.06 | 36.22 | CCNB2;RANBP1;CCNB1;PCNA;CHEK1;CDK1;NDC80;AURKA;KIF15 |