Table 2 PLD dose adjustment in MSHFS patients

Therapy

Neoadjuvant therapy

67

Adjuvant therapy

139

First cycle dose (mg)

70

3

60–69

64

50–59

113

40–49

25

< 39

1

MSHFS appearance cycle

1

18

2

86

3

78

4

24

Cumulative dose at the time of MSHFS (mg)

> 199

20

180–199

24

160–179

18

140–159

36

120–139

26

100–119

53

80–99

11

60–79

10

40–59

8

Reduce the dose (%)

20%

42

25%

19

Extension of time (Day)

7

33

6

17

5

39