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Table 3 Indicators of birth size associated with risk of molecular subtypes of breast cancer

From: The association of women’s birth size with risk of molecular breast cancer subtypes: a cohort study

  Luminal A Luminal B (HER2-) Luminal B (HER2+) HER2 type Triple negative
n HR (95% CI) a n HR (95% CI)a n HR (95% CI)a N HR (95% CI)a n HR (95% CI) a
Birth weight (g)
  < 3000 37 1.0 (0.6–1.5) 26 1.1 (0.7–1.8) 7 0.6 (0.2–1.4) 4 1.2 (0.3–4.1) 7 0.7 (0.3–2.0)
 3000–3499 77 1.0 63 1.0 28 1.0 9 1.0 15 1.0
 3500–3999 82 1.2 (0.9–1.7) 65 1.2 (0.8–1.7) 21 0.9 (0.5–1.6) 7 0.8 (0.3–2.2) 12 1.0 (0.5–2.2)
  ≥ 4000 31 1.3 (0.8–1.9) 16 0.8 (0.4–1.3) 9 1.1 (0.5–2.4) 4 1.1 (0.3–3.8) 5 1.2 (0.4–3.4)
 Per 500 g increment 227 1.1 (1.0–1.3) 170 0.9 (0.8–1.1) 65 1.2 (0.9–1.6) 24 1.0 (0.6–1.4) 39 1.3 (0.9–1.8)
Birth length (cm)b
  < 49 35 1.0 23 1.0 6 1.0 5 1.0 5 1.0
 49 20 0.6 (0–4-1.1) 16 0.7 (0.3–1.2) 11 1.8 (0.6–5.1) 2 0.4 (0.1–2.0) 6 2.0 (0.5–7.4)
 50 60 1.1 (0.7–1.7) 46 1,0 (0.6–1.7) 14 1.3 (0.5–3.7) 7 0.7 (0.2–2.3) 9 1.8 (0.5–6.2)
 51 35 0.9 (0.5–1.4) 37 1.2 (0.7–2.0) 10 1.3 (0.4–3.8) 5 0.8 (0.2–3.0) 7 2.1 (0.6–7.9)
  > 51 77 1.2 (0.8–1.9) 49 1.0 (0.6–1.7) 24 2.0 (0.8–5.5) 5 0.5 (0.1–2.0) 12 2.4 (0.7–8.5)
 Per 2 cm increment 227 1.2 (1.0–1.3) 171 1.0 (0.8–1.2) 65 1.3 (1.0–1-7) 24 0.8 (0.5–1.3) 39 1.4 (1.0–1.9)
< 50 cm 112 1.0 81 1.0 31 1.0 14 1.0 19 1.0
≥50 115 1.2 (0.9–1.6) 90 1.2 (0.9–1.7) 34 1.2 (0.7–2.0) 10 0.9 (0.4–2.2) 20 1.5 (0.8–3.1)
Head circumference (cm)
  < 34 40 1.0 26 1.0 10 1.0 5 1.0 9 1.0
 34 50 1.0 (0.6–1.5) 39 1.0 (0.6–1.7) 16 1.2 (0.5–2.6) 7 0.9 (0.3–3.0) 7 0.7 (0.3–2.0)
 35 59 1.0 (0.6–1.5) 50 1.1 (0.7–1.8) 19 1.2 (0.5–2.6) 6 0.6 (0.2–2.1) 10 0.9 (0.3–2.4)
 36 46 1.1 (0.7–1.7) 34 1.1 (0.6–1.8) 11 1.0 (0.4–2.4) 5 0.8 (0.2–2.8) 7 1.0 (0.3–2.7)
  ≥ 37 31 1.3 (0.8–2.2) 22 1.3 (0.7–2.3) 8 1.4 (0.5–3.5) 1 0.3 (0.0–2.6) 6 1.5 (0.5–4.6)
Per 1.5 cm increment 226 1.1 (0.9–1.2) 171 1.0 (0.9–1.2) 64 1.1 (0.9–1.4) 24 0.9 (0.5–1.2) 39 1.1 (0.8–1.5)
  1. aHRs adjusted for gestational age at birth, birth order, birth year in 5 year categories, maternal age at birth, and maternal socioeconomic status
  2. bLunn McNeil likelihood-ratio test, p = 0.7