Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study

Sato, Akira; Matsubayashi, Keisuke; Morishima, Toshitaka; Nakata, Kayo; Kawakami, Koji; Miyashiro, Isao

doi:10.1186/s12885-021-08011-3

Table 1 Characteristics of newly diagnosed cancer patients according to index cancer site

From: Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study

Index Cancer Site	Lung			Stomach			Colorectum			Breast			Cervix uteri			Corpus uteri
Index Cancer Site	Total	Prior^a		Total	Prior^a		Total	Prior^a		Total	Prior^a		Total	Prior^a		Total	Prior^a
N = 275,720	N	N	%	N	N	%	N	N	%	N	N	%	N	N	%	N	N	%
Total	56,930	6309	11.1	78,092	7382	9.5	77,032	5757	7.5	47,860	1588	3.3	7686	206	2.7	8120	542	6.7
Sex
Male	39,040	4628	11.9	54,479	5800	10.6	44,535	3841	8.6
Female	17,890	1681	9.4	23,613	1582	6.7	32,497	1916	5.9	47,860	1588	3.3	7686	206	2.7	8120	542	6.7
Age, years
Median (IQR)	70 (63–76)	73 (67–78)		71 (63–77)	74 (68–79)		70 (62–77)	73 (67–79)		60 (48–69)	69 (61–76)		52 (41–66)	67 (56–77)		59 (51–68)	62 (52–71)
15–39	455	15	3.3	864	8	0.9	961	10	1.0	3034	23	0.8	1706	10	1.2	437	18	4.1
40–44	551	20	3.6	919	17	1.8	1191	29	2.4	4556	35	0.8	998	8	2.1	447	25	5.6
45–49	1032	39	3.8	1572	39	2.5	1974	47	2.4	5737	61	1.1	806	15	4.2	761	57	7.5
50–54	1965	98	5.0	2954	107	3.6	3508	103	2.9	4885	91	1.9	650	13	5.4	1121	87	7.8
55–59	4197	242	5.8	5962	292	4.9	6471	277	4.3	5589	137	2.5	712	21	3.5	1375	59	4.3
60–64	7902	671	8.5	10,240	658	6.4	10,754	559	5.2	6376	214	3.4	733	26	4.3	1261	64	5.1
65–69	10,790	1110	10.3	13,402	1197	8.9	13,329	936	7.0	5889	279	4.7	635	19	5.1	1000	67	6.7
70–74	12,028	1419	11.8	15,508	1686	10.9	14,275	1259	8.8	4693	277	5.9	550	27	7.3	753	68	9.0
75–79	10,191	1503	14.7	13,493	1774	13.1	12,180	1255	10.3	3429	222	6.5	396	29	7.5	534	42	7.9
80–84	5702	875	15.3	8550	1077	12.6	7568	857	11.3	2160	153	7.1	271	19	10.5	298	42	14.1
85–99	2117	317	15.0	4628	527	11.4	4821	425	8.8	1512	96	6.3	229	19	7.8	133	13	9.8
Method of cancer detection
Screening and medical check-up	8417	399	4.7	11,938	553	4.6	11,299	466	4.1	9565	167	1.7	1580	27	3.3	702	50	7.1
Incidental detection^b	19,365	4222	21.8	20,721	4003	19.3	15,244	2728	17.9	3938	666	16.9	742	56	11.7	1173	180	15.3
Other or unknown^c	29,148	1688	5.8	45,433	2826	6.2	50,489	2563	5.1	34,357	755	2.2	5364	123	3.6	6245	312	5.0
Cancer stage
Localized	17,540	2986	17.0	43,352	5027	11.6	35,289	3152	8.9	28,498	1087	3.8	3566	90	5.0	5314	373	7.0
Regional lymph nodes	7112	785	11.0	9327	725	7.8	15,269	1036	6.8	11,856	343	2.9	382	6	3.2	266	15	5.6
Regional extension	8188	782	9.6	8477	509	6.0	9034	581	6.4	2179	44	2.0	2529	80	3.8	1577	85	5.4
Distant metastasis	20,480	1388	6.8	12,500	688	5.5	12,838	659	5.1	2340	48	2.1	666	12	3.8	587	37	6.3
Other or unknown	3610	368	10.2	4436	433	9.8	4602	329	7.1	2987	66	2.2	543	18	5.1	376	32	8.5
Treatment
Radiotherapy only	3116	471	15.1	48	14	29.2	93	6	6.5	214	3	1.4	823	38	4.9	67	6	9.0
Chemotherapy only	15,195	1076	7.1	7455	543	7.3	1974	142	7.2	1984	38	1.9	224	4	4.0	175	13	7.4
Chemoradiotherapy	7394	515	7.0	166	38	22.9	184	13	7.1	185	4	2.2	1177	32	2.9	21	3	14.3
Surgery only	15,772	2665	16.9	29,975	2514	8.4	40,687	3331	8.2	16,277	741	4.6	2645	64	5.2	4059	298	7.3
Surgery plus chemotherapy or radiotherapy	6839	634	9.3	13,618	772	5.7	23,206	1176	5.1	24,665	639	2.6	2057	37	3.7	3277	178	5.4
Other or unknown	8614	948	11.0	26,830	3501	13.0	10,888	1089	10.0	4535	163	3.6	760	31	5.7	521	44	8.4
Diagnostic year
2004–2005	7288	538	7.4	9969	635	6.4	9151	498	5.4	5650	143	2.5	1025	23	4.2	876	61	7.0
2006–2007	8407	803	9.6	11,542	892	7.7	11,295	743	6.6	6913	206	3.0	1098	26	3.8	1029	60	5.8
2008–2009	8880	856	9.6	12,498	1048	8.4	11,833	825	7.0	7297	244	3.3	1174	28	4.1	1136	75	6.6
2010–2011	10,240	1195	11.7	13,806	1373	9.9	13,565	1052	7.8	8596	270	3.1	1416	39	4.7	1542	104	6.7
2012–2013	10,641	1379	13.0	15,047	1661	11.0	15,074	1252	8.3	9050	337	3.7	1451	39	4.8	1720	122	7.1
2014–2015	11,474	1538	13.4	15,230	1773	11.6	16,114	1387	8.6	10,354	388	3.7	1522	51	4.9	1817	120	6.6

Abbreviation: IQR interquartile range
Categorical variables between cancer patients with and without prior cancer were compared using Pearson’s chi-square test. Significant differences (P ≤ 0.05) were found in all categories except for diagnostic year in corpus uterine cancer patients. ^aNewly diagnosed cancer patients with prior cancer of the specified site. ^bDetected during follow-up examination for another disease. ^cGenerally detected from the occurrence of subjective symptoms

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