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Fig. 6 | BMC Cancer

Fig. 6

From: Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer

Fig. 6

Mutation analysis of human breast cancer cell lines by digital PCR. The figure shows dPCR dot plots for cellular mRNA (a, c, e and g) and matched EV-RNA (b, d, f and h) indicating wild-type (WT) and mutant (MT) copies for breast cancer cell lines BT20 (PIK3CA p.H1047R), T47D (PIK3CA p.H1047R), MDA-MB-435 (BRAF p.V600E(c.1799T > A)) and MDA-MB-231 (KRAS p.G13D). Dots represent wells with mutant copies (blue), wild-type copies (red), both wild-type and mutant copies (green), empty wells (yellow), and undetermined wells (grey). VAF: Variant Allele Frequency

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