Table 3 Cox regression analysis of the progression-free survival

Age

0.99 (0.96–1.01)

0.344

–

–

Sex (male)

1.04 (0.53–2.04)

0.751

–

–

Smoking history

0.79 (0.28–2.23)

0.608

–

ECOG PS 0–1

0.10 (0.03–0.29)

< 0.001

0.09 (0.02–0.33)

< 0.001

Brain metastasis

1.61 (0.82–3.17)

0.119

1.22 (0.58–2.56)

0.594

Cause of crizotinib treatment failure: Resistance^a

2.64 (1.26–5.51)

0.009

2.75 (1.26–5.99)

0.011

Prior chemotherapy

1.18 (0.61–2.27)

0.630

–

–

Alectinib vs. ceritinib

0.61 (0.31–1.13)

0.135

0.68 (0.33–1.37)

0.277