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Table 6 Hematology analyses from female BALB/c mice injected with IRDye800CW-nimotuzumab

From: Pre-clinical study of IRDye800CW-nimotuzumab formulation, stability, pharmacokinetics, and safety

Parameter

baseline

day 2

day 14

(female)

vehicle

Nz-800CW

vehicle

Nz-800CW

mean ± sd

mean ± sd

mean ± sd

unit

GR

7.0 ± NA

4.6 ± 1.4

4.1 ± 2.3

2.8 ± 0.3

3.1 ± 1.6

%

Hct

0.5 ± 0.1

0.4 ± 0.1

0.4 ± 0.0

0.5 ± 0.1

0.5 ± 0.0

L/L

Hgb

160 ± 22

138 ± 22

140 ± 12

156 ± 19

161 ± 13

g/L

LY

77.8 ± NA

79.8 ± 4.3

82.9 ± 2.3

85.2 ± 1.2

83.6 ± 6.9

%

MCH

18.9 ± 0.3

18.6 ± 1.2

17.2 ± 0.3

19.0 ± 0.5

19.2 ± 0.2

gp

MCHC

322 ± 1.3

320 ± 1.7

321 ± 0.6

321 ± 1.2

322 ± 0.5

g/L

MCV

58.7 ± 1.0

58.0 ± 3.5

53.7 ± 1.0

59.1 ± 1.6

59.5 ± 0.6

fL

MO

15.2 ± NA

15.5 ± 2.9

13.0 ± 1.2

12.1 ± 1.2

13.4 ± 5.3

%

Plt

703 ± 173

602 ± 160

453 ± 318

630 ± 217

711 ± 137

×10^9/L

RBC

9.0 ± 0.4

8.2 ± 0.5

7.5 ± 0.8

8.8 ± 0.2

8.8 ± 0.6

×10^12/L

RDW

19.3 ± 7.1

19.1 ± 1.2

20.8 ± 0.9

15.7 ± 0.7

15.5 ± 0.3

%

WBC

0.9 ± 0.4

1.1 ± 0.3

2.2 ± 0.5

1.9 ± 1.5

1.0 ± 0.4

× 10^9/L

  1. Abbreviations: Nz-800 IRDye800CW-nimotuzumab, GR granulocytes, Hct hematocrits, hgb hemoglobin, LY lymphocytes, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, MCV mean corpuscular volume, MO monocytes, Plt platelets, RBC red blood cells, RDW red blood cell distribution width, WBC white blood cell