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Table 5 Multivariate Cox proportional hazards models of survival among patients who received systemic anti-cancer treatment

From: Intensity of end-of-life health care and mortality after systemic anti-cancer treatment in patients with advanced lung cancer

Characteristic

Unadjusted

HR (95%CI)

Adjusteda

HR (95%CI)

Adjusted

p

Sex

 Female

1

1

 

 Male

1.56 (1.24–1.96)

1.38 (1.08–1.76)

0.011

Age

  ≤ 49

1

1

 

 50–59

2.11 (1.14–3.89)

2.2 (1.18–4.08)

0.013

 60–69

1.80 (1.00–3.25)

1.87 (1.02–3.4)

0.042

 70–79

1.45 (0.80–2.64)

1.58 (0.86–2.92)

0.14

 80 ≥

1.67 (0.84–3.31)

1.93 (0.96–3.88)

0.065

Comorbidities (yes vs no)

 Diabetes

0.94 (0.71–1.26)

1.06 (0.78–1.43

.716

 Cardiovascular

0.84 (1.05–1.43)

0.89 (0.69–1.14)

.347

 Atrial fibrillation

1.00 (0.78–1.30)

0.99 (0.75–1.31)

.956

 COPD

0.99 (0.80–1.25)

0.9 (0.71–1.13)

0.353

Disease status

 Newly diagnosed

1.14 (0.88–1.47)

1.26 (0.96–1.65)

.009

 Recurrence

1

1

 

Stage

 II

0.87 (0.21–3.52)

1.18 (0.28–4.98)

.824

 III

1

1

 

 IV

0.96 (0.76–1.20)

1.11 (0.87–1.4)

.402

Histology

 Adenocarcinoma

1

1

 

 Squamous

1.58 (1.21–2.06)

1.54 (1.15–2.08)

.004

 SCLC

1.63 (1.19–2.24)

1.48 (1.07–2.05)

.019

 Other

1.70 (1.29–2.24)

1.59 (1.18–2.14)

.002

Other cancer treatment

 Radiotherapy

1.02 (0.83–1.26)

0.9 (0.72–1.12)

.334

  1. HR Hazard ratio, CI Confidence interval, p Probability, COPD Chronic obstructive pulmonary disease, SCLC Small cell lung cancer
  2. aAdjusted on all patient and disease related variables in the table. Values in bold are significant at P < .05