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Table 9 For genes with at least five hemimethylation sites in tumor samples

From: Statistical and bioinformatic analysis of hemimethylation patterns in non-small cell lung cancer

Gene name

Count

Family

Gene Description

RGS14

17

regulator of G protein signaling 14

MEX3A

16

mex-3 RNA binding family member A

WT1

11

TF, TS

WT1 transcription factor

PRDM16

10

OG, TF, TCG

PR/SET domain 16

ZDHHC9

10

zinc finger DHHC-type containing 9

AGAP2

8

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

GNAS

8

OG

GNAS complex locus

EXOC3L2

8

exocyst complex component 3 like 2

PTPRN2

7

protein tyrosine phosphatase receptor type N2

FANK1

7

fibronectin type III and ankyrin repeat domains 1

UNC93B1

7

unc-93 homolog B1, TLR signaling regulator

IGSF9B

7

immunoglobulin superfamily member 9B

GNAS-AS1

7

GNAS antisense RNA 1

MAD1L1

7

mitotic arrest deficient 1 like 1

TSPAN9

7

tetraspanin 9

PTPRM

7

protein tyrosine phosphatase receptor type M

TP73

6

TF

tumor protein p73

IFT140

6

intraflagellar transport 140

NFATC1

6

TF

nuclear factor of activated T cells 1

DGKA

6

diacylglycerol kinase alpha

FMNL1

6

formin like 1

CACNA1I

6

calcium voltage-gated channel subunit alpha1 I

LOC101927636

6

RNA Gene affiliated with the lncRNA class

HDAC4

5

TF

histone deacetylase 4

IRX2

5

TF, HP

iroquois homeobox 2

ANKRD33B

5

ankyrin repeat domain 33B

LINC00537

5

Long Intergenic Non-Protein Coding RNA 537

NOTCH1

5

OG, TCG

notch receptor 1

ANO2

5

anoctamin 2

CACNA1H

5

calcium voltage-gated channel subunit alpha1 H

RUNX3

5

TF

runt related transcription factor 3

SIX3

5

TF, HP

SIX homeobox 3

FZD7

5

frizzled class receptor 7

ADGRA2

5

adhesion G protein-coupled receptor A2

IFFO1

5

intermediate filament family orphan 1

CHTF18

5

chromosome transmission fidelity factor 18

TMEM204

5

transmembrane protein 204

RECQL5

5

RecQ like helicase 5

SMIM5

5

small integral membrane protein 5

MAPK1

5

PK

mitogen-activated protein kinase 1

SYN1

5

synapsin I

  1. The gene name, corresponding number of hemimethylated sites (i.e., count), specified gene family, and a description of the gene are formatted in the table’s respective columns. Descriptions are derived from the Molecular Signature Database [14] and the GeneCards database [15]. Certain genes are indicated as members of specific gene families, as shown in the third column: “TF” for transcription factor, “TS” for tumor suppressor, “OG” for oncogene, “HP” for homeodomain protein, “TCG” for translocated cancer gene, and “PK” for protein kinase