The association of sex-biased ATRX mutation in female gastric cancer patients with enhanced immunotherapy-related anticancer immunity

Table 2 Univariate and multivariate Cox regression analysis of clinical pathologic features

Characteristics	Classification	Univariate analysis			Multivariate analysis
Characteristics	Classification	HR	95%CI	P value	HR	95%CI	P value
Age	< 60
Age	> = 60	1.734	1.128–2.667	0.012	2.021	1.310–3.118	0.001
Sex	female
Sex	male	1.263	0.844–1.889	0.256
ATRX	wild type
ATRX	mutant type	0.122	0.017–0.875	0.036	0.132	0.018–0.947	0.044
Grade	grade1			0.270
	grade2	1.159	0.159–8.445	0.884
	grade3	1.581	0.220–11.383	0.649
Stage	Stage I			0.002			0.001
	Stage II	1.413	0.642–3.108	0.390	1.561	0.708–3.444	0.270
	Stage III	2.333	1.117–4.873	0.024	2.519	1.204–5.270	0.014
	Stage IV	3.634	1.578–8.370	0.002	4.334	1.875–10.017	0.001
MSI status	MSS			0.116
	MSI-L	1.326	0.795–2.212	0.280
	MSI-H	0.659	0.467–1.111	0.118
TMB	Low
TMB	High	0.625	0.433–0.904	0.012	0.738	0.504–1.079	0.116
PDL1	Low
PDL1	High	0.427	0.208–0.878	0.021	0.464	0.225–0.956	0.037

MSI-H Microsatellite instability-high, MSS Microsatellite stability, MSI-L Microsatellite instability-low

ISSN: 1471-2407