Table 1 Univariate and multivariate Cox regression analysis of the risk score, clinical variables, and survival in the training, testing and validation cohorts

 Grade (ref. WHO IV)

0.101

0.070–0.171

< 0.001

0.377

0.208–0.682

0.001

 Sex (ref. Female)

0.966

0.664–1.404

0.854

 Age (median years, ref. < 42)

1.91

1.310–2.786

< 0.001

0.937

0.633–1.387

0.746

 1p19q status (ref. codeletion)

5.442

2.901–10.206

< 0.001

2.6

1.337–5.048

0.005

 Risk score (continuous)

2.718

2.269–3.256

< 0.001

2.002

1.584–2.530

< 0.001

 Grade (ref. WHO IV)

0.106

0.079–0.143

< 0.001

0.327

0.204–0.500

< 0.001

 Sex (ref. Female)

1.129

0.854–1.495

0.394

 Age (median, ref. < 42)

5.25

3.654–7.544

< 0.001

3.954

2.005–4.163

< 0.001

 1p19q status (ref. codeletion)

4.793

2.951–7.785

< 0.001

3.166

1.873–5.352

< 0.001

 Risk score (continuous)

2.076

1.853–2.325

< 0.001

1.243

1.063–1.469

0.007

 Grade (ref. WHO IV)

0.062

0.028–0.136

< 0.001

0.057

0.021–0.155

< 0.001

 Sex (ref. Female)

0.685

0.419–1.12

0.131

 Age (median, ref. < 42)

1.026

0.628–1.677

0.917

 1p19q status (ref. codeletion)

2.033

1.002–4.125

0.049

2.758

1.275–5.969

0.009

 Risk score (continuous)

18.376

6.881–49.075

< 0.001

4.457

1.472–13.491

0.008