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Table 1 Univariate and multivariate Cox regression analysis of the risk score, clinical variables, and survival in the training, testing and validation cohorts

From: Identification and validation of a five-lncRNA prognostic signature related to Glioma using bioinformatics analysis

Variates Univariate Cox analysis Multivariate Cox analysis
HR 95%CI P HR 95%CI P
CGGA glioma training set (n = 181)
 Grade (ref. WHO IV) 0.101 0.070–0.171 < 0.001 0.377 0.208–0.682 0.001
 Sex (ref. Female) 0.966 0.664–1.404 0.854    
 Age (median years, ref. < 42) 1.91 1.310–2.786 < 0.001 0.937 0.633–1.387 0.746
 1p19q status (ref. codeletion) 5.442 2.901–10.206 < 0.001 2.6 1.337–5.048 0.005
 Risk score (continuous) 2.718 2.269–3.256 < 0.001 2.002 1.584–2.530 < 0.001
TCGA glioma testing set (n = 541)
 Grade (ref. WHO IV) 0.106 0.079–0.143 < 0.001 0.327 0.204–0.500 < 0.001
 Sex (ref. Female) 1.129 0.854–1.495 0.394    
 Age (median, ref. < 42) 5.25 3.654–7.544 < 0.001 3.954 2.005–4.163 < 0.001
 1p19q status (ref. codeletion) 4.793 2.951–7.785 < 0.001 3.166 1.873–5.352 < 0.001
 Risk score (continuous) 2.076 1.853–2.325 < 0.001 1.243 1.063–1.469 0.007
Our glioma validation set (n = 91)
 Grade (ref. WHO IV) 0.062 0.028–0.136 < 0.001 0.057 0.021–0.155 < 0.001
 Sex (ref. Female) 0.685 0.419–1.12 0.131    
 Age (median, ref. < 42) 1.026 0.628–1.677 0.917    
 1p19q status (ref. codeletion) 2.033 1.002–4.125 0.049 2.758 1.275–5.969 0.009
 Risk score (continuous) 18.376 6.881–49.075 < 0.001 4.457 1.472–13.491 0.008
  1. Abbreviations: HR hazard ratio; CI confidence interval