Table 3 Correlation between clinicopathological factors and CAF PD-L1 expression (SP142 Assay)
Factors | PD-L1-positive (n = 16) | PD-L1-negative (n = 45) | p-value |
|---|---|---|---|
Age (years old; median ± SD) | |||
68 ± 10 | 64 ± 16 | 0.465 | |
Menopausal status | |||
premenopausal | 0 | 9 | 0.096 |
postmenopausal | 16 | 35 | |
unknown | 0 | 1 | |
Tumour size (mm) | |||
≤ 20 | 7 | 24 | 0.570 |
> 20 | 9 | 21 | |
Pathological stage | |||
I + II | 13 | 40 | 0.422 |
III | 3 | 5 | |
Lymph node status | |||
positive | 3 | 11 | 0.321 |
negative | 13 | 20 | |
not tested | 0 | 14 | |
Lymphatic invasion | |||
positive | 15 | 37 | 0.423 |
negative | 1 | 8 | |
Venous invasion | |||
positive | 11 | 26 | 0.557 |
negative | 5 | 19 | |
Nottingham histlogical grade | |||
1 + 2 | 6 | 23 | 0.395 |
3 | 10 | 22 | |
Ki-67 labeling index (LI) | |||
high | 9 | 19 | 0.749 |
low | 7 | 22 | |
not tested | 0 | 4 | |
Stromal TILs | |||
LPB | 9 | 10 | 0.025 |
non-LPBC | 7 | 35 | |
PD-L1 on stromal TILs (SP142) | |||
positive | 13 | 12 | < 0.001 |
negative | 3 | 32 | |
not tested | 0 | 1 | |
Adjuvant chemotherapy | |||
performed | 7 | 27 | 0.539 |
not performed | 7 | 17 | |
undetermined | 2 | 1 | |