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Table 2 Univariate and multivariate analyses of prognostic factors affecting post-hepatectomy early recurrence in the derivation cohort

From: Artificial neural network model to predict post-hepatectomy early recurrence of hepatocellular carcinoma without macroscopic vascular invasion

Variables

Univariate Cox regression

Multivariate Cox regression

β

HR (95CI%)

P value

β

HR (95CI%)

P value

Age > 60 year

−0.289

0.749 (0.558, 1.005)

0.054

   

Sex, Male

0.226

1.254 (0.855, 1.840)

0.247

   

Positive HBsAg

0.524

1.688 (1.107, 2.575)

0.015

0.286

1.331 (0.839, 2.110)

0.225

Positive HBeAg

0.246

1.278 (0.970, 1.685)

0.081

   

HBV-DNA > 104 IU/mL

0.540

1.717 (1.329, 2.218)

< 0.001

0.435

1.544 (1.188, 2.008)

0.001

Antiviral therapy

0.313

1.368 (1.059, 1.767)

0.017

0.068

1.071 (0.800, 1.433)

0.645

PT > 13 s

0.320

1.378 (1.063, 1.786)

0.016

0.179

1.196 (0.911, 1.570)

0.197

T-Bil > 17.1 μmol/L

0.210

1.234 (0.938, 1.623)

0.132

   

ALB > 40 g/L

−0.427

0.652 (0.499, 0.853)

0.002

−0.147

0.863 (0.639, 1.165)

0.336

ALT > 40 U/L

0.123

1.131 (0.866, 1.476)

0.366

   

AST > 40 U/L

0.588

1.801 (1.394, 2.325)

< 0.001

0.111

1.118 (0.835, 1.496)

0.445

GGT > 60 U/L

0.580

1.785 (1.383, 2.305)

< 0.001

0.388

1.474 (1.131, 1.920)

0.004

Ascites

0.355

1.427 (0.983, 2.071)

0.062

   

Child-Pugh grade

0.508

1.662 (1.071, 2.579)

0.024

0.076

1.079 (0.682, 1.707)

0.745

AFP > 400 ng/mL

0.591

1.806 (1.396, 2.337)

< 0.001

0.422

1.525 (1.170, 1.987)

0.002

CSPH

0.224

1.251 (0.838, 1.868)

0.273

   

Tumor size > 5 cm

0.816

2.262 (1.719, 2.976)

< 0.001

0.456

1.578 (1.172, 2.214)

0.003

Multiple number

−0.095

0.910 (0.661, 1.253)

0.562

   

Cirrhosis

0.231

1.260 (0.976, 1.626)

0.076

   

Tumor differentiation (grade III / IV)

0.631

1.880 (1.447, 2.442)

< 0.001

0.503

1.653 (1.264, 2.163)

< 0.001

Tumor encapsulation

−0.210

0.810 (0.628, 1.046)

0.107

   

Microvascular invasion

0.551

1.734 (1.343, 2.239)

< 0.001

0.356

1.428 (1.095, 1.862)

0.009

Satellite nodules

0.927

2.526 (1.813, 3.518)

< 0.001

0.399

1.490 (1.006, 2.206)

0.046

Necrosis

0.421

1.524 (1.175, 1.977)

0.002

0.044

1.045 (0.785, 1.391)

0.761

Resection margin > 1 cm

−0.041

0.960 (0.607, 1.518)

0.862

   

Operation time > 200 min

0.360

1.434 (1.110, 1.852)

0.006

0.209

1.233 (0.939, 1.619)

0.132

Blood loss > 400 mL

0.635

1.887 (1.448, 2.459)

< 0.001

0.342

1.407 (1.065, 1.860)

0.016

Blood transfusion

0.424

1.528 (1.061, 2.200)

0.023

0.050

1.051 (0.701, 1.577)

0.808

Major resection

0.511

1.668 (1.291, 2.553)

< 0.001

0.057

1.059 (0.796, 1.409)

0.696

  1. Abbreviations: HBsAg hepatitis B surface antigen, HBeAg hepatitis Be antigen, HBV-DNA hepatitis B virus DNA load, PT prothrombin time, T-Bil total bilirubin, ALB albumin, ALT alanine transaminase, AST aspartic aminotransferase, GGT γ-glutamyl transpeptadase, AFP α-fetoprotein, CSPH clinically significant portal hypertension
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