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Table 3 Multivariate Logistic Regression for the risk factors of liver metastases at initial diagnosis of breast Cancer in the SEER database

From: Risk and prognostic factors of breast cancer with liver metastases

Variable Among Entire Cohort
Multivariate
OR (95% CI) P Value
Age at diagnosis, y
 18–40 1[Reference]  
 41–60 0.59 (0.54–0.66) < 0.001*
 61–80 0.46 (0.41–0.51) < 0.001*
  > 80 0.46 (0.40–0.54) < 0.001*
Race
 White 1[Reference]  
 Black 1.54 (1.41–1.67) < 0.001*
 Hispanic 0.82 (0.74–0.91) < 0.001*
 Asian or Pacific Islander 0.81 (0.72–0.92) 0.001*
 American Indian/Alaska Native 0.93 (0.59–1.38) 0.725
 Unknown 0.38 (0.19–0.68) < 0.001*
Marital status
 Unmarried a 1[Reference]  
 Married 0.64 (0.60–0.68) < 0.001*
 Unknown 0.83 (0.72–0.96) 0.013*
Insurance status
 Uninsured b 1[Reference]  
 Insured 0.53 (0.45–0.63) < 0.001*
 Unknown 0.48 (0.35–0.67) < 0.001*
Histology
 Infiltrating duct carcinoma 1[Reference]  
 Lobular carcinoma 0.68 (0.59–0.77) < 0.001*
 Infiltrating duct and lobular carcinoma 0.66 (0.55–0.79) < 0.001*
 Other types c 1.25 (1.14–1.37) < 0.001*
Pathological Grade
 I 1[Reference]  
 II 3.89 (3.28–4.65) < 0.001*
 III/IV 8.59 (7.26–10.23) < 0.001*
 Unknown 20.75 (17.32–25.02) < 0.001*
Extrahepatic metastatic sites to lung, brain and bone, No
 0 1[Reference]  
 1 58.49 (53.84–63.57) < 0.001*
 2 123.15 (110.89–136.76) < 0.001*
 All 3 246.17 (195.34–310.33) < 0.001*
 Unknown 299.10 (240.01–372.94) < 0.001*
Subtype
 HR+/HER2− 1[Reference]  
 HR+/HER2+ 3.13 (2.87–3.41) < 0.001*
 HR−/HER2+ 4.75 (4.30–5.25) < 0.001*
 Triple-negative 1.92 (1.73–2.12) < 0.001*
 Unknown 1.48 (1.31–1.68) < 0.001*
  1. Notes: a including divorced, separated, single (never married), and widowed; b including insured, Insured/No specifics Any Medicaid; c including other histology of invasive breast cancer except Infiltrating duct carcinoma, Lobular carcinoma and Infiltrating duct and lobular carcinoma; + denotes positive; − denotes negative; * denotes a statistically significant P-value; HER2 Human epidermal growth factor receptor 2, HR Hormone receptor, OR Odds ratio, CI Confidence interval