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Fig. 1 | BMC Cancer

Fig. 1

From: Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cells

Fig. 1

CRISPR screening identifies ERAD as a target modulating the efficacy of FTS. a Basic flow of the genome-wide CRISPR screen for genes modulating FTS sensitivity. b Gene Ontology (GO) pathway analysis of genes with gRNA dropouts upon FTS treatment. c Gene Set Enrichment Analysis (GSEA) showing enrichment of genes in the ERAD pathway indicated by the enrichment score and p-value. d Gene dropout rank based on beta score. Top ERAD pathway genes were labeled. Blue color depicted gene dropouts with FDR < 0.05

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