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Table 2 Univariate and multivariate Cox analysis for BC patients with BM in surgery group

From: Surgery for primary tumor benefits survival for breast cancer patients with bone metastases: a large cohort retrospective study

 

Univariate Cox analysis

Multivariate Cox analysis

 

HR

95%CI

P

HR

95%CI

P

Age

  < 51

1

   

1

   

 51–78

1.344

1.087

1.662

0.006

1.320

1.054

1.653

0.016

  > 78

3.250

2.367

4.463

0.000

3.038

2.129

4.336

0.000

Race

 Black

1

   

1

   

 Other

0.643

0.421

0.982

0.041

0.642

0.417

0.990

0.045

 White

0.682

0.537

0.866

0.002

0.712

0.554

0.915

0.008

Sex

 Female

1

       

 Male

1.486

0.838

2.637

0.176

    

Primary site

 Central portion

1

       

 Upper-inner

0.998

0.661

1.506

0.993

    

 Lower-inner

1.271

0.794

2.034

0.317

    

 Upper-outer

1.121

0.810

1.552

0.492

    

 Lower-outer

0.877

0.562

1.366

0.561

    

 Others

1.025

0.737

1.425

0.885

    

Laterality

 Left

1

       

 Right

0.908

0.759

1.086

0.290

    

Histological type

 Ductal

1

   

1

   

 Lobular

1.048

0.838

1.311

0.681

1.083

0.845

1.387

0.528

 Others

1.774

1.164

2.705

0.008

1.891

1.231

2.905

0.004

Grade

 I

1

   

1

   

 II

1.187

0.800

1.762

0.395

1.307

0.874

1.955

0.192

 III

1.959

1.337

2.871

0.001

1.968

1.313

2.952

0.001

 IV

8.574

2.036

36.105

0.003

4.009

0.909

17.675

0.067

T stage

 T1

1

       

 T2

1.750

1.217

2.516

0.003

    

 T3

2.355

1.612

3.439

0.000

    

 T4

2.163

1.477

3.168

0.000

    

N stage

 N0 + N1

1

   

1

   

 N2 + N3

1.358

1.136

1.623

0.001

1.221

1.010

1.477

0.039

Surgery

 BCS

1

   

1

   

 Mastectomy

1.466

1.201

1.789

0.000

1.253

1.007

1.558

0.043

Radiotherapy

 No

1

       

 Yes

0.813

0.680

0.972

0.023

    

Chemotherapy

 No

1

   

1

   

 Yes

0.774

0.646

0.929

0.006

0.729

0.585

0.909

0.005

Brain metastasis

 No

1

   

1

   

 Yes

2.177

1.359

3.488

0.001

2.694

1.656

4.382

0.000

Liver metastasis

 No

1

   

1

   

 Yes

1.993

1.585

2.506

0.000

2.207

1.725

2.824

0.000

Lung metastasis

 No

    

1

   

 Yes

1.647

1.314

2.066

0.000

1.274

1.003

1.619

0.047

Tumor size, cm

  < 2

1

   

1

   

 2–5

1.665

1.145

2.420

0.008

1.370

0.938

2.003

0.104

  > 5

2.504

1.716

3.653

0.000

1.818

1.223

2.703

0.003

Breast subtype

 HR−/HER2+

1

   

1

   

 HR+/HER2-

1.414

0.899

2.223

0.134

1.770

1.097

2.854

0.019

 HR+/HER2+

1.052

0.634

1.746

0.845

1.160

0.691

1.946

0.574

 HR−/HER2-

3.584

2.203

5.832

0.000

3.603

2.185

5.943

0.000

Insurance status

 Uninsured

1

       

 Insured

0.621

0.365

1.057

0.079

    

Marital status

 Unmarried

1

       

 Married

0.743

0.622

0.888

0.001

    
  1. BC breast cancer, BM bone metastases,
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