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Table 1 Concentration ranges of the ten chemotherapeutic drugs and lovastatin in the S. cerevisiae assays

From: Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism

Drug Principal mechanism of action Concentration Range (μM)
Cisplatin DNA crosslinking 12.4–105
Cyclophosphamide Alkylating agent which binds to DNA 49.4–420
Doxorubicin Intercalates DNA, blocking replication 24.7–210
Epothilone Binds to microtubules, blocking cell division 1.1–9.3
Etoposide Topoisomerase II inhibitor 0.165–1.4
5-Fluorouracil Antimetabolite: blocks thymidylate synthetase 0.92–8.07
Gemcitabine Antimetabolite: incorporated into DNA in place of dCTP 14.4–123
Methotrexate Antimetabolite: binds to dihydrofolate reductase 8.24–70.0
Rapamycin mTOR inhibitor 0.33–2.80
Tamoxifen Selective estrogen receptor modulator (SERM) 24.7–210
Lovastatin Competitive inhibitor of HMG-CoA reductase 12.7–108