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Fig. 7 | BMC Cancer

Fig. 7

From: Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism

Fig. 7

Tamoxifen and lovastatin dual-drug assays in human breast cancer cell lines, MCF7 (ac), MDA-MB-231 (d- f), and SKBR3 (gi), and lung adenocarcinoma (jl). Shown are the single agent dose response data and the Loewe additivity model (synergy level) matrices. Note the variability of the lovastatin dose responses between cell lines (a, d, g, j). The tamoxifen single agent dose responses vary to a lesser degree (b, e, h, k); the EC50 values are clustered about the 1 μg/ml concentration. The Loewe synergy matrices (c, f, i, l), all of which include significant synergism and antagonism, are quite dissimilar. The concentration space of the estrogen receptor-positive MCF7 cell line (c) resembles that obtained with S. cerevisiae (see Fig. 2d). N = 3 for each cell line

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